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Publication Name World Journal of Gastrointestinal Endoscopy
Manuscript ID 119473
Country United States
Received
2026-01-28 03:15
Peer-Review Started
2026-01-28 03:20
First Decision by Editorial Office Director
2026-02-26 07:59
Return for Revision
2026-02-28 02:29
Revised
2026-03-11 18:56
Publication Fee Transferred
2026-03-18 14:31
Second Decision by Editor
2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-08 08:09
Articles in Press
2026-05-08 08:09
Edit the Manuscript by Language Editor
2026-05-11 14:02
Typeset the Manuscript
2026-06-03 00:27
Publish the Manuscript Online
2026-06-10 02:21
ISSN 1948-5190 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Polyposis in Lynch syndrome: A retrospective study
Manuscript Source Unsolicited Manuscript
All Author List Nadeen Sarsour, Eve Karloski, Beth Dudley, Shikhar Uttam, Brenda Diergaarde and Randall E Brand
ORCID
Author(s) ORCID Number
Randall E Brand http://orcid.org/0000-0002-4136-3313
Funding Agency and Grant Number
Corresponding Author Randall E Brand, Department of Medicine, University of Pittsburgh, 200 Lorthop St., Pittsburgh, PA 15213, United States. brandre@upmc.edu
Key Words Colorectal cancer; Polyposis; Lynch syndrome; Hereditary colon cancer; Genetics
Core Tip The purpose of this paper is to further describe and investigate polyposis (≥ 10 lifetime adenomas) in patients with a diagnosis of Lynch syndrome (LS). Previously known as hereditary nonpolyposis syndrome, more data has emerged described polyposis occurring in these patients. We used a registry of patients with LS at our institution to find possible associations and commonalities among patients who had ≥ 10 lifetime adenomas in order to help determine which of these high-risk patients may be at higher risk for developing adenomas. We discovered that in our cohort, patients with polyposis more commonly had pathogenic variants in the MSH2 and MSH6 genes.
Publish Date 2026-06-10 02:21
Citation

Sarsour N, Karloski E, Dudley B, Uttam S, Diergaarde B, Brand RE. Polyposis in Lynch syndrome: A retrospective study. World J Gastrointest Endosc 2026; 18(6): 119473

URL https://www.wjgnet.com/1948-5190/full/v18/i6/119473.htm
DOI https://doi.org/10.4253/wjge.v18.i6.119473
Full Article (PDF) WJGE-18-119473-with-cover.pdf
Manuscript File 119473_Auto_Edited_094210.docx
Answering Reviewers 119473-answering-reviewers.pdf
Audio Core Tip 119473-audio.m4a
Biostatistics Review Certificate 119473-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 119473-conflict-of-interest-statement.pdf
Copyright License Agreement 119473-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119473-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119473-institutional-review-board-statement.pdf
Peer-review Report 119473-peer-reviews.pdf
Scientific Misconduct Check 119473-scientific-misconduct-check.png
Scientific Editor Work List 119473-scientific-editor-work-list.pdf
CrossCheck Report 119473-crosscheck-report.pdf