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Articles Published Processes
7/14/2026 7:33:59 AM | Browse: 2 | Download: 0
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Received |
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2026-01-29 03:01 |
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Peer-Review Started |
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2026-01-29 03:01 |
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First Decision by Editorial Office Director |
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2026-02-06 10:48 |
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Return for Revision |
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2026-02-06 10:48 |
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Revised |
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2026-02-12 11:06 |
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Publication Fee Transferred |
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2026-02-13 00:45 |
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Second Decision by Editor |
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2026-03-13 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-13 07:02 |
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Articles in Press |
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2026-03-13 07:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-23 00:26 |
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Publish the Manuscript Online |
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2026-07-14 07:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shao-Pu Hu, Yan-Ru Cai, Yang Liu, Yu-Xi Guo, Xue-Mei Jia, Jian-Ming Jiang and Qian Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine |
No. 2025213 |
| Hebei Natural Science Foundation |
No. H2024423041 |
| Hebei Natural Science Foundation |
No. H2023423001 |
| Hebei Natural Science Foundation |
No. H2024423025 |
| Merit-based Funding Project for Hebei Postdoctoral Researchers’ Scientific Research |
No. B2024005036 |
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| Corresponding Author |
Qian Yang, MD, PhD, Professor, Department of Gastrointestinal Disease, The First Affiliated Hospital, Hebei University of Chinese Medicine, No. 389 Zhongshan East Road, Changan District, Shijiazhuang 050011, Hebei Province, China. yangqian6909@163.com |
| Key Words |
Hua-Zhuo-Jie-Du formula; Colitis-associated colorectal cancer; Network pharmacology; Transcriptomics; Phosphatidylinositol 3-kinase/protein kinase B signaling pathway |
| Core Tip |
Hua-Zhuo-Jie-Du formula (HZJDF) has been clinically proven to be effective at preventing colitis-associated colorectal cancer (CAC), but the mechanism for this requires further investigation. This study utilized ultra-high performance liquid chromatography-high-resolution mass spectrometry analysis, network pharmacology, and transcriptomics in an integrated approach to predict the material basis and potential mechanism of action of HZJDF in treating CAC. Furthermore, the prediction results were verified through animal and cell experiments. The results indicated that HZJDF effectively alleviated the tumorigenesis of CAC via inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway. |
| Publish Date |
2026-07-14 07:33 |
| Citation |
Hu SP, Cai YR, Liu Y, Guo YX, Jia XM, Jiang JM, Yang Q. Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway. World J Gastroenterol 2026; 32(27): 119490
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i27/119490.htm |
| DOI |
https://doi.org/10.3748/wjg.119490 |
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