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6/24/2026 9:13:59 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 119494
Country China
Received
2026-01-29 02:56
Peer-Review Started
2026-01-29 02:57
First Decision by Editorial Office Director
2026-02-14 07:25
Return for Revision
2026-02-14 07:25
Revised
2026-03-04 11:53
Publication Fee Transferred
2026-03-08 13:33
Second Decision by Editor
2026-03-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-25 06:08
Articles in Press
2026-03-25 06:08
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-27 00:31
Publish the Manuscript Online
2026-06-24 09:13
ISSN 1948-9366 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Clinical Trials Study
Article Title Effects of esketamine on perioperative renal injury in paediatric patients undergoing living donor liver transplantation
Manuscript Source Unsolicited Manuscript
All Author List Hong-Xia Li, Gui-Zhu Cao, Yi-Qi Weng, Ai-Li Dong, Wei Gao, Min Zhu, Lu Che and Wen-Li Yu
ORCID
Author(s) ORCID Number
Yi-Qi Weng http://orcid.org/0000-0002-9963-9837
Wen-Li Yu http://orcid.org/0009-0007-1258-4698
Funding Agency and Grant Number
Funding Agency Grant Number
Research Fund for Liquid Therapy in Anesthesiology Medicine YLGX-MZ-2022008
the Tianjin Key Clinical Speciality (Anaesthesiology) Construction Project
the Tianjin Key Medical Construction Project TJYXZDXK-3-022C
Corresponding Author Wen-Li Yu, Department of Anaesthesiology, Tianjin First Central Hospital, No. 24, Fukang Road, Nankai District, Tianjin 300192, Nankai District, China. 5020201005@nankai.edu.cn
Key Words Esketamine; Paediatric living-donor liver transplantation; Acute kidney injury; Ischaemia-reperfusion injury; Renal protection; Inflammatory factors; Paediatric anaesthesia
Core Tip This randomized controlled trial demonstrates that, compared with the control group, intraoperative esketamine administration significantly attenuates the increase in serum creatinine levels following ischemia-reperfusion injury and attenuates the systemic inflammatory response in pediatric patients undergoing living donor liver transplantation. The renoprotective effects are mediated by the suppression of tumour necrosis factor-α, interleukin-18, and neutrophil gelatinase-associated lipocalin, alongside hemodynamic stabilization. Esketamine may be considered as a component of anesthetic management to mitigate perioperative renal injury in this high-risk population.
Publish Date 2026-06-24 09:13
Citation

Li HX, Cao GZ, Weng YQ, Dong AL, Gao W, Zhu M, Che L, Yu WL. Effects of esketamine on perioperative renal injury in paediatric patients undergoing living donor liver transplantation. World J Gastrointest Surg 2026; 18(6): 119494

URL https://www.wjgnet.com/1948-9366/full/v18/i6/119494.htm
DOI https://doi.org/10.4240/wjgs.119494
Full Article (PDF) WJGS-18-119494-with-cover.pdf
CONSORT 2010 Statement 119494-CONSORT-2010-statement.pdf
Manuscript File 119494_Auto_Edited_091832.docx
Answering Reviewers 119494-answering-reviewers.pdf
Audio Core Tip 119494-audio.mp3
Biostatistics Review Certificate 119494-biostatistics-statement.pdf
Clinical Trial Registration Statement 119494-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 119494-conflict-of-interest-statement.pdf
Copyright License Agreement 119494-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119494-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119494-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119494-non-native-speakers.pdf
Peer-review Report 119494-peer-reviews.pdf
Scientific Misconduct Check 119494-scientific-misconduct-check.png
Scientific Editor Work List 119494-scientific-editor-work-list.pdf
CrossCheck Report 119494-crosscheck-report.pdf