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Publication Name World Journal of Clinical Oncology
Manuscript ID 119535
Country Germany
Received
2026-01-30 01:40
Peer-Review Started
2026-01-30 01:42
First Decision by Editorial Office Director
2026-02-10 10:28
Return for Revision
2026-02-10 10:28
Revised
2026-04-07 06:33
Publication Fee Transferred
Second Decision by Editor
2026-05-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-08 08:39
Articles in Press
2026-05-08 08:39
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-09 14:37
Publish the Manuscript Online
2026-06-22 08:40
ISSN 2218-4333 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Retrospective Cohort Study
Article Title Risk factors for postoperative pathological fractures in lower extremity soft tissue sarcoma patients undergoing limb-sparing surgery
Manuscript Source Unsolicited Manuscript
All Author List Axel Horsch, Christopher Baus, Julian Deisenhofer, Andre Lunz, Andreas Geisbüsch and Burkhard Lehner
ORCID
Author(s) ORCID Number
Axel Horsch http://orcid.org/0000-0002-6487-030X
Funding Agency and Grant Number
Funding Agency Grant Number
Heidelberg University
Corresponding Author Axel Horsch, Associate Professor, Department of Orthopedics, University Hospital Heidelberg, Schlierbacher Landstraße 200a, Heidelberg 69118, Baden-Württemberg, Germany. axel.horsch@med.uni-heidelberg.de
Key Words Soft tissue sarcoma; Limb-sparing surgery; Postoperative pathological fracture; Radiotherapy; Bone resection
Core Tip Postoperative pathologic fractures are an underrecognized late complication following limb-sparing surgery for lower extremity soft tissue sarcoma (STS). In this retrospective cohort of 266 patients with long-term follow-up, fractures occurred predominantly in the femur and often several years after treatment. Partial bone resection and osteoporosis were independently associated with increased fracture risk, whereas radiotherapy showed an elevated but not statistically significant association. These findings underscore the importance of long-term surveillance and careful risk stratification in patients undergoing limb-sparing management for STS.
Publish Date 2026-06-22 08:40
Citation

Horsch A, Baus C, Deisenhofer J, Lunz A, Geisbüsch A, Lehner B. Risk factors for postoperative pathological fractures in lower extremity soft tissue sarcoma patients undergoing limb-sparing surgery. World J Clin Oncol 2026; 17(6): 119535

URL https://www.wjgnet.com/2218-4333/full/v17/i6/119535.htm
DOI https://doi.org/10.5306/wjco.119535
Full Article (PDF) WJCO-17-119535-with-cover.pdf
STROBE Statement 119535-STROBE-statement.pdf
Manuscript File 119535_Auto_Edited_104648.docx
Answering Reviewers 119535-answering-reviewers.pdf
Audio Core Tip 119535-audio.mp3
Biostatistics Review Certificate 119535-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 119535-conflict-of-interest-statement.pdf
Copyright License Agreement 119535-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119535-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119535-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119535-non-native-speakers.pdf
Peer-review Report 119535-peer-reviews.pdf
Scientific Misconduct Check 119535-scientific-misconduct-check.png
Scientific Editor Work List 119535-scientific-editor-work-list.pdf
CrossCheck Report 119535-crosscheck-report.pdf