Publication Name	World Journal of Diabetes
Manuscript ID	11954
Country	United States

Received	2014-06-13 19:00
Peer-Review Started	2014-06-14 16:12
To Make the First Decision	2014-06-27 11:50
Return for Revision	2014-12-23 10:53
Revised	2014-12-26 00:00
Second Decision	2015-01-04 16:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-12 14:17
Articles in Press	2015-01-12 14:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-01 15:05
Publish the Manuscript Online	2015-04-20 09:13

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Emergency Medicine
Manuscript Type	Field of Vision
Article Title	Ménage-à-trois of bariatric surgery, bile acids and the gut microbiome
Manuscript Source	Invited Manuscript
All Author List	Rajendra Raghow
Funding Agency and Grant Number
Corresponding Author	Rajendra Raghow, PhD, Professor, Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States. rraghow@uthsc.edu
Key Words	Vertical sleeve gastrectomy; Bile acids; Farnesoid-X-receptor; Type-2 diabetes mellitus; Gut microbiome; Bariatric surgery
Core Tip	The report of Ryan et al, raises a number of questions with regard to the prevailing notion that mechanical restriction of the stomach and weight loss are the sole mechanisms that mediate the therapeutic effects of bariatric surgery. The authors showed that both lowering of body mass index and improved glucose tolerance after vertical sleeve gastrectomy (VSG) surgery were mechanistically linked to an altered composition of circulating bile acids and their ability to modulate farnesoid-X receptor (FXR) mediated signaling mechanisms. Additionally, it was observed that the wild type and FXR knockout mice, after receiving VSG surgery, were significantly different with respect to the make up of their gut microbiomes. Finally, the experiments revealed that the composition of gut microbiota in wild type VSG and FXR-/- VSG mice were highly correlated with their differential abilities to lose weight and acquire glucose tolerance.
Publish Date	2015-04-20 09:13
Citation	Raghow R. Ménage-à-trois of bariatric surgery, bile acids and the gut microbiome. World J Diabetes 2015; 6(3): 367-370
URL	http://www.wjgnet.com/1948-9358/full/v6/i3/367.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i3.367

Full Article (PDF)	WJD-6-367.pdf
Full Article (Word)	WJD-6-367.doc
Manuscript File	11954-Review.docx
Answering Reviewers	11954-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	11954-Conflict-of-interest statement.pdf
Copyright License Agreement	11954-Copyright assignment.pdf
Peer-review Report	11954-Peer review(s).pdf
Scientific Misconduct Check	11954-CrossCheck.jpg
Scientific Editor Work List	11954-Scientific editor work list.pdf