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Articles Published Processes
8/20/2026 6:54:18 AM | Browse: 0 | Download: 0
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Received |
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2026-02-02 01:12 |
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Peer-Review Started |
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2026-02-02 01:12 |
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First Decision by Editorial Office Director |
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2026-03-20 10:14 |
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Return for Revision |
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2026-03-20 10:14 |
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Revised |
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2026-03-29 09:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-08 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-08 11:02 |
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Articles in Press |
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2026-05-08 11:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-11 04:18 |
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Publish the Manuscript Online |
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2026-08-20 06:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Epiregulin-EGFR-ERK1/2 signaling as a therapeutic axis for rescuing mesenchymal stem cell dysfunction in inflammatory periodontal niches
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kruthika Prakash, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran and Byeong-Cheol Ahn |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program Through the National Research Foundation of Korea |
NRF-2022R1I1A1A01068652 |
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| Corresponding Author |
Byeong-Cheol Ahn, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, 680, Gukchaebosang ro, Jung gu, Daegu 41944, South Korea. abc2000@knu.ac.kr |
| Key Words |
Epiregulin; Mesenchymal stem cells; Periodontitis; Inflammatory niche; Epidermal growth factor receptor-extracellular signal-regulated kinase signaling |
| Core Tip |
Epiregulin restores inflammation-impaired bone marrow mesenchymal stem cell function via epidermal growth factor receptor-extracellular signal-regulated kinase signaling, highlighting its potential as a promising therapeutic target for periodontal regeneration under inflammatory conditions. By activating this pathway, epiregulin rescues key stem cell functions, including proliferation, migration, and osteogenic differentiation, that are suppressed by inflammatory stimuli such as tumor necrosis factor-alpha, offering a mechanistically driven and inflammation-resilient strategy for periodontal tissue regeneration and clinical translation. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Prakash K, ArulJothi KN, Rajendran RL, Gangadaran P, Ahn BC. Letter to the Editor: Epiregulin-EGFR-ERK1/2 signaling as a therapeutic axis for rescuing mesenchymal stem cell dysfunction in inflammatory periodontal niches. World J Stem Cells 2026; 18(8): 119568
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/119568.htm |
| DOI |
https://doi.org/10.4252/wjsc.119568 |
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