| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Depleting apolipoprotein C3 alleviates acute pancreatitis in hamsters but not in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gong-Lie Chen, Kai-Kai Lu, Wen-Xi Zhang, Ping-Ping Lai, Yi-Tong Xu, Yu-Fei Han, Zi-Hao Zhou, Wei Huang, Yu-Hui Wang, Yue Zhang and Xun-De Xian |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Jiangxi Provincial Natural Science Foundation, China |
20212BAB216022 |
| National Natural Science Foundation of China |
82270479 and 82501040 |
| China Postdoctoral Science Foundation |
2025M771442 |
|
| Corresponding Author |
Xun-De Xian, PhD, Professor, Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, No. 38 Xueyuan Road, Huayuanlu Subdistrict, Haidian District, Beijing 100191, China. xianxunde@bjmu.edu.cn |
| Key Words |
Acute pancreatitis; Apolipoprotein C3; Hypertriglyceridemia; Hamster model; Inflammation |
| Core Tip |
Hypertriglyceridemia (HTG) has been shown to cause acute pancreatitis (AP), but the mechanisms remain unclear. This study identified apolipoprotein C3 (ApoC3) as a key player in AP pathogenesis. In three hamster AP models, ApoC3 deficiency significantly reduced pancreatic injury by improving lipid metabolism, suppressing inflammatory cytokine production, and limiting immune cell infiltration. In contrast, ApoC3 deficiency showed no protective effect in mice, underscoring the importance of appropriate model selection. Our findings establish ApoC3 as a critical molecular bridge between dyslipidemia and pancreatic inflammation, highlighting its potential as a novel therapeutic target for HTG-related AP. |
| Publish Date |
2026-08-04 07:19 |
| Citation |
Chen GL, Lu KK, Zhang WX, Lai PP, Xu YT, Han YF, Zhou ZH, Huang W, Wang YH, Zhang Y, Xian XD. Depleting apolipoprotein C3 alleviates acute pancreatitis in hamsters but not in mice. World J Gastroenterol 2026; 32(31): 119570
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i31/119570.htm |
| DOI |
https://doi.org/10.3748/wjg.119570 |
