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Articles Published Processes
8/19/2026 1:55:07 AM | Browse: 2 | Download: 1
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Received |
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2026-02-02 03:04 |
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Peer-Review Started |
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2026-02-02 03:05 |
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First Decision by Editorial Office Director |
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2026-02-26 08:19 |
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Return for Revision |
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2026-02-26 08:19 |
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Revised |
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2026-03-17 15:57 |
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Publication Fee Transferred |
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2026-03-22 06:13 |
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Second Decision by Editor |
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2026-04-24 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-24 10:59 |
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Articles in Press |
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2026-04-24 10:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-12 00:12 |
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Publish the Manuscript Online |
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2026-08-19 01:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Lin Guo, Shang-Qing Zhang, Hao-Nan Zheng, Yan Chi and Hua-Hong Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Beijing Municipality |
7212110 |
| Peking University First Hospital Youth Clinical Research Special Fund |
2018CR06 |
| Peking University First Hospital Interdisciplinary Clinical Research Special Fund |
2019CR42 |
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| Corresponding Author |
Yan Chi, Associate Professor, Chief Physician, MD, Department of Gastroenterology, Peking University First Hospital, No. 8 Xishiku Road, Xicheng District, Beijing 100034, China. chiyan@bjmu.edu.cn |
| Key Words |
Cladosporium; Mycobiota; Mast cell; Dectin-1; Visceral hypersensitivity |
| Core Tip |
Gut mycobiota are linked to visceral hypersensitivity (VH) in irritable bowel syndrome (IBS); however, the specific role of fungi in IBS remains unexplored. This study explored the role of the gut mycobiota in VH associated with diarrhea-predominant IBS. We identified Cladosporium as a key fungal genus enriched in diarrhea-predominant IBS patients and demonstrated that Cladosporium cladosporioides (C. cladosporioides) alleviates IBS-VH in mice. Mechanistically, C. cladosporioides reduces inflammatory cytokine levels, inhibits mast cell activation, and downregulates dectin-1/nuclear factor kappa B signaling. These findings suggest C. cladosporioides as a potential therapeutic probiotic for IBS-VH, highlighting the role of this gut fungus in modulating IBS pathogenesis. |
| Publish Date |
2026-08-19 01:55 |
| Citation |
Guo CL, Zhang SQ, Zheng HN, Chi Y, Wang HH. Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation. World J Gastroenterol 2026; 32(34): 119605
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i34/119605.htm |
| DOI |
https://doi.org/10.3748/wjg.119605 |
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