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Publication Name World Journal of Clinical Oncology
Manuscript ID 119607
Country China
Received
2026-02-02 02:48
Peer-Review Started
2026-02-02 02:48
First Decision by Editorial Office Director
2026-02-27 08:51
Return for Revision
2026-02-27 08:51
Revised
2026-03-11 20:28
Publication Fee Transferred
2026-04-06 14:48
Second Decision by Editor
2026-05-11 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-11 09:47
Articles in Press
2026-05-11 09:47
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-09 14:38
Publish the Manuscript Online
2026-06-22 08:40
ISSN 2218-4333 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Prospective Study
Article Title Clinical study of Xianjun formula combined with standard western therapy in metastatic colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Lin-Feng Wang, Yu-Xing Sun, Jiang-Yu Bian and Tong Zhang
ORCID
Author(s) ORCID Number
Lin-Feng Wang http://orcid.org/0009-0000-1763-5043
Yu-Xing Sun http://orcid.org/0009-0001-5576-6455
Jiang-Yu Bian http://orcid.org/0009-0003-0374-4662
Tong Zhang http://orcid.org/0000-0002-4041-0499
Funding Agency and Grant Number
Funding Agency Grant Number
Xiyuan Hospital of China Academy of Chinese Medical Sciences No.XYZX0201-22
Corresponding Author Tong Zhang, Associate Chief Physician, PhD, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1, Xiyuan Playground, Haidian District, Beijing, China Academy of Chinese Medical Sciences Xiyuan Hospital, Beijing 100091, China. ashtray7654@126.com
Key Words Xianjun Formula; Metastatic colorectal cancer; Microsatellite stable; Late-line therapy; Overall survival; Integrative medicine
Core Tip Most metastatic colorectal cancer (mCRC) patients are microsatellite stable (MSS) and derive limited benefit from immune checkpoint inhibitor-based therapies, especially in late-line settings. This prospective, multicenter, single-arm clinical trial explores the feasibility and survival benefit of integrating Xianjun Formula, a traditional Chinese medicine compound, with standard Western therapies in refractory MSS mCRC. By targeting the tumor immune microenvironment, this study aims to provide preliminary clinical evidence supporting an integrative therapeutic strategy for patients lacking effective treatment options.
Publish Date 2026-06-22 08:40
Citation

Wang LF, Sun YX, Bian JY, Zhang T. Clinical study of Xianjun formula combined with standard western therapy in metastatic colorectal cancer. World J Clin Oncol 2026; 17(6): 119607

URL https://www.wjgnet.com/2218-4333/full/v17/i6/119607.htm
DOI https://doi.org/10.5306/wjco.119607
Full Article (PDF) WJCO-17-119607-with-cover.pdf
CONSORT 2010 Statement 119607-CONSORT-2010-statement.pdf
Manuscript File 119607_Auto_Edited_104647.docx
Answering Reviewers 119607-answering-reviewers.pdf
Audio Core Tip 119607-audio.mp3
Biostatistics Review Certificate 119607-biostatistics-statement.pdf
Clinical Trial Registration Statement 119607-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 119607-conflict-of-interest-statement.pdf
Copyright License Agreement 119607-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 119607-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 119607-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 119607-non-native-speakers.pdf
Peer-review Report 119607-peer-reviews.pdf
Scientific Misconduct Check 119607-scientific-misconduct-check.png
Scientific Editor Work List 119607-scientific-editor-work-list.pdf
CrossCheck Report 119607-crosscheck-report.pdf