| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Smoking-induced liver injury and related diseases: Molecular mechanisms, pathogenic amplification, and clinical implications
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin Wen, Tian-Yi Xue, Yan-Hui Yang, Yan-Pei Mai, Qin-Shuo Wang, Xiao-Xiao Wang, Dong-Bo Chen, Hong-Song Chen and Zi-Xing Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82570754 |
| Peking University People’s Hospital Scientific Research Development Funds |
RS2024-06 |
|
| Corresponding Author |
Zi-Xing Wang, Assistant Professor, PhD, Peking University Hepatology Institute, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. wangzixing@pkuph.edu.cn |
| Key Words |
Smoking; Hepatic disease; Liver injury; Chronic liver disease progression; Smoking cessation |
| Core Tip |
Cigarette smoking is an underrecognized yet independent risk factor across the spectrum of liver diseases. This review synthesizes mechanistic, epidemiologic, and genetic evidence demonstrating that smoking induces hepatocellular injury through oxidative stress, mitochondrial dysfunction, inflammation, immune dysregulation, and genotoxicity, while synergizing with viral hepatitis, metabolic dysfunction-associated steatotic liver disease, alcohol use, and other hepatic risk factors to accelerate disease progression. We also highlight the clinical implications of smoking assessment and cessation in hepatology practice and identify key knowledge gaps regarding reversibility, legacy effects, and emerging tobacco products. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Wen X, Xue TY, Yang YH, Mai YP, Wang QS, Wang XX, Chen DB, Chen HS, Wang ZX. Smoking-induced liver injury and related diseases: Molecular mechanisms, pathogenic amplification, and clinical implications. World J Hepatol 2026; 18(6): 119664
|
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/119664.htm |
| DOI |
https://doi.org/10.4254/wjh.119664 |
