9/22/2026 3:20:35 AM | Browse: 3 | Download: 4
| Publication Name | World Journal of Gastroenterology |
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| Manuscript ID | 119693 |
| Country | Spain |
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| ISSN | 1007-9327 (print) and 2219-2840 (online) |
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| Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||||||||||||
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| Manuscript Type | Observational Study | ||||||||||||||||
| Article Title | Real-world effectiveness and safety of risankizumab in multirefractory Crohn’s disease: A multicenter AIRIS-Crohn registry analysis | ||||||||||||||||
| Manuscript Source | Invited Manuscript | ||||||||||||||||
| All Author List | Antonio M Caballero-Mateos, Teresa Valdés-Delgado, Raúl Olmedo-Martín, Patricia Romero-Cara, María del Mar Martín-Rodríguez, Ana Lancho Muñoz, Melody Moreno-Barrueco, Raúl Gijón-Villanova, Nuria Fernández-Moreno, Francisco J Rodríguez-González, Álvaro Hernández-Martínez, Ana María Trapero-Martínez, Ana Bejarano-García, José Manuel Benitez Cantero, Francisco J Mata-Perdigón, Antonia Sáez-Díaz and Federico Argüelles-Arias | ||||||||||||||||
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| Corresponding Author | Teresa Valdés-Delgado, Department of Gastroenterology, Virgen Macarena University Hospital, Dr. Fedriani, Seville 41009, Spain. teresavaldes4@hotmail.com | ||||||||||||||||
| Key Words | Crohn’s disease; Inflammatory bowel disease; Risankizumab; Real-world evidence; Interleukin-12/23 | ||||||||||||||||
| Core Tip | Risankizumab, a selective interleukin-23p19 inhibitor, emerges as a promising therapeutic option for patients with multirefractory Crohn’s disease. This multicenter real-world study of 205 patients demonstrates that risankizumab rapidly achieves clinical remission (49% at week 12) and maintains steroid-free remission in over 40% of patients throughout one-year follow-up. The excellent safety profile and high treatment persistence (> 90%) establish interleukin-23 blockade as a key strategy for patients with limited biologic alternatives in routine clinical practice. | ||||||||||||||||
| Publish Date | 2026-09-22 03:20 | ||||||||||||||||
| Citation |
Caballero-Mateos AM, Valdés-Delgado T, Olmedo-Martín R, Romero-Cara P, Martín-Rodríguez MDM, Lancho Muñoz A, Moreno-Barrueco M, Gijón-Villanova R, Fernández-Moreno N, Rodríguez-González FJ, Hernández-Martínez Á, Trapero-Martínez AM, Bejarano-García A, Benitez Cantero JM, Mata-Perdigón FJ, Sáez-Díaz A, Argüelles-Arias F. Real-world effectiveness and safety of risankizumab in multirefractory Crohn’s disease: A multicenter AIRIS-Crohn registry analysis. World J Gastroenterol 2026; 32(42): 119693 |
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| URL | https://www.wjgnet.com/1007-9327/full/v32/i42/119693.htm | ||||||||||||||||
| DOI | https://doi.org/10.3748/wjg.119693 |
| Full Article (PDF) | WJG-32-119693-with-cover.pdf |
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| STROBE Statement | 119693-STROBE-statement.pdf |
| Manuscript File | 119693_Auto_Edited_031532.docx |
| Answering Reviewers | 119693-answering-reviewers.pdf |
| Audio Core Tip | 119693-audio.m4a |
| Biostatistics Review Certificate | 119693-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 119693-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 119693-copyright-assignment.pdf |
| Signed Informed Consent Form(s) or Document(s) | 119693-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 119693-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 119693-non-native-speakers.pdf |
| Supplementary Material | 119693-supplementary-material.pdf |
| Peer-review Report | 119693-peer-reviews.pdf |
| Scientific Misconduct Check | 119693-scientific-misconduct-check.png |
| CrossCheck Report | 119693-crosscheck-report.pdf |