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Articles Published Processes
9/7/2026 2:26:33 AM | Browse: 1 | Download: 0
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Received |
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2026-02-03 01:25 |
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Peer-Review Started |
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2026-02-03 01:28 |
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First Decision by Editorial Office Director |
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2026-03-12 08:57 |
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Return for Revision |
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2026-03-12 08:57 |
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Revised |
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2026-03-26 09:02 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-13 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-13 10:36 |
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Articles in Press |
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2026-04-13 10:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-31 01:13 |
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Publish the Manuscript Online |
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2026-09-07 02:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Biological interpretation of baseline hepatitis B surface antigen and cirrhosis in determining interferon treatment duration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ling-Feng Zou, Shao-Ding Yu, Yan Luo and Cheng-Long Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) |
2023MSXM060 |
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| Corresponding Author |
Cheng-Long Wang, MD, PhD, Department of Pathology, Chongqing Traditional Chinese Medicine Hospital, No. 6 Panxi 7 Branch Road, Liangjiang New Area, Chongqing 400021, China. qq171909771@gmail.com |
| Key Words |
Chronic hepatitis B; Hepatitis B surface antigen; Sinusoidal capillarization; Liver sinusoidal endothelial cells; Cirrhosis |
| Core Tip |
We interpret baseline hepatitis B surface antigen and cirrhosis as pathological surrogates for the virus-host equilibrium. High hepatitis B surface antigen may indicate an entrenched viral reservoir and may be associated with persistent antigenic pressure that contributes to antiviral immune dysfunction, while cirrhotic vascular remodeling may reduce the efficiency of immune surveillance. Consequently, extended interferon therapy may be more frequently required in patients with these biological and structural constraints. |
| Publish Date |
2026-09-07 02:26 |
| Citation |
Zou LF, Yu SD, Luo Y, Wang CL. Biological interpretation of baseline hepatitis B surface antigen and cirrhosis in determining interferon treatment duration. World J Gastroenterol 2026; 32(38): 119697
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i38/119697.htm |
| DOI |
https://doi.org/10.3748/wjg.119697 |
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