| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Alarm from the peritoneum: Gastrointestinal perforations in cancer patients, with a focus on perforations of unknown origin
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Manlio Monti, Bianca Ceredi, Nicolò Paganelli, Roberto Vespignani, Alice Andalò, Paolo De Angelis, Nicola Gentili, Ilaria Massa, Andrea Roncadori, Valentina Danesi and William Balzi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ricerca Corrente by the Italian Ministry of Health |
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| Corresponding Author |
Valentina Danesi, PhD, Outcome Research, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Via Piero Maroncelli, 40, Meldola 47014, Emilia-Romagna, Italy. valentina.danesi@irst.emr.it |
| Key Words |
Gastrointestinal perforation; Spontaneous perforation; Cancer patients; Prognostic factors; Emergency surgery; Overall survival; Real-world evidence |
| Core Tip |
In this single-center retrospective study, a small but clinically relevant subset of gastrointestinal perforations occurred without an identifiable cause. Patients with perforation of unknown origin showed distinctive clinical and pathological features compared with cancer-related and cancer-unrelated cases, including a higher burden of comorbidities, particularly arterial hypertension, a different distribution of primary tumors (lung and kidney cancers), and preferential involvement of the colon and small intestine. Although outcomes appeared broadly comparable across groups, these findings suggest that patient-related factors may contribute to spontaneous perforation, highlighting an under-recognized clinical scenario in oncology practice. |
| Publish Date |
2026-09-10 00:49 |
| Citation |
Monti M, Ceredi B, Paganelli N, Vespignani R, Andalò A, De Angelis P, Gentili N, Massa I, Roncadori A, Danesi V, Balzi W. Alarm from the peritoneum: Gastrointestinal perforations in cancer patients, with a focus on perforations of unknown origin. World J Gastroenterol 2026; 32(39): 119719
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i39/119719.htm |
| DOI |
https://doi.org/10.3748/wjg.119719 |
