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Articles Published Processes
7/9/2026 6:58:26 AM | Browse: 1 | Download: 0
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Received |
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2026-02-10 09:37 |
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Peer-Review Started |
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2026-02-11 02:56 |
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First Decision by Editorial Office Director |
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2026-03-05 08:50 |
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Return for Revision |
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2026-03-05 08:50 |
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Revised |
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2026-04-01 08:34 |
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Publication Fee Transferred |
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2026-05-21 09:02 |
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Second Decision by Editor |
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2026-05-18 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-18 09:30 |
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Articles in Press |
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2026-05-18 09:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-30 07:33 |
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Publish the Manuscript Online |
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2026-07-09 06:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Nicotinamide mononucleotide-loaded thermosensitive hydrogel promotes diabetic wound healing via antibacterial and antioxidant synergy in a mouse model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fei Peng, Yang-Yang Li, Yuan Tang, Shang-Xue Sun, Yu-Qi Zhu, Xin-Yin Zhang and Huan-Zhang Zhu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Huan-Zhang Zhu, Academic Fellow, School of Life Sciences, Fudan University, No. 2005 Songhu Road, Xinjiangwancheng Street, Yangpu District, Shanghai 200433, China. hzzhu@fudan.edu.cn |
| Key Words |
Diabetic ulcer; Thermosensitive composite hydrogel; Hydrogel dressing; Nicotinamide mononucleotide; Polyhexamethylene biguanide |
| Core Tip |
In this study, a thermosensitive Pluronic F127/polyhexamethylene biguanide composite hydrogel loaded with antioxidant nicotinamide mononucleotide was prepared, which showed sustained strong antibacterial and antioxidant properties and favorable biosafety. In vitro, hydrogel inhibited bacteria, and boosted cell migration and angiogenesis. In mouse models, it markedly accelerated diabetic ulcer healing via faster re-epithelialization, reduced inflammation, elevated collagen deposition and angiogenesis, as well as upregulating vascular endothelial growth factor and transforming growth factor-β1. This hydrogel is a safe, effective novel dressing for clinical diabetic ulcer treatment. |
| Publish Date |
2026-07-09 06:58 |
| Citation |
Peng F, Li YY, Tang Y, Sun SX, Zhu YQ, Zhang XY, Zhu HZ. Nicotinamide mononucleotide-loaded thermosensitive hydrogel promotes diabetic wound healing via antibacterial and antioxidant synergy in a mouse model. World J Diabetes 2026; 17(7): 119741
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i7/119741.htm |
| DOI |
https://doi.org/10.4239/wjd.119741 |
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