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Articles Published Processes
5/27/2026 8:10:55 AM | Browse: 1 | Download: 0
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Received |
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2026-02-10 02:22 |
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Peer-Review Started |
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2026-02-10 02:23 |
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First Decision by Editorial Office Director |
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2026-02-27 08:55 |
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Return for Revision |
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2026-02-27 08:55 |
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Revised |
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2026-03-03 04:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-02 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-02 07:30 |
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Articles in Press |
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2026-04-02 07:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-21 00:39 |
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Publish the Manuscript Online |
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2026-05-27 08:10 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Precision immunotherapy in oesophageal squamous cell carcinoma: Molecular pathogenesis and checkpoint inhibitor response prediction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Meer M Chisthi, Sindhu Viswanath and Krishnakumar G Kuttanchettiyar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Meer M Chisthi, Associate Professor, Department of General Surgery, Government Medical College Kollam, Parippally, Kollam, Parippally 691574, Kerala, India. meerchisthi.m@tmc.kerala.gov.in |
| Key Words |
Oesophageal squamous cell carcinoma; Precision immunotherapy; Immune checkpoint inhibitors; Molecular pathogenesis; Predictive biomarkers; Tumour microenvironment |
| Core Tip |
Precision immunotherapy is transforming the management of oesophageal squamous cell carcinoma (ESCC). This review synthesizes current knowledge on the molecular drivers of ESCC and the complex tumour-immune interactions that dictate response to immune checkpoint inhibitors (ICIs). We detail established and emerging biomarkers-such as programmed death-ligand 1 expression, tumour mutational burden, and circulating tumour DNA-for predicting ICI efficacy. The discussion extends to mechanisms of resistance and future directions, including novel immune targets and multi-omics integration for personalized treatment strategies, aiming to guide clinicians and researchers toward more effective, tailored immunotherapeutic interventions. |
| Publish Date |
2026-05-27 08:10 |
| Citation |
Chisthi MM, Viswanath S, Kuttanchettiyar KG. Precision immunotherapy in oesophageal squamous cell carcinoma: Molecular pathogenesis and checkpoint inhibitor response prediction. World J Gastrointest Pharmacol Ther 2026; 17(2): 119778 |
| URL |
https://www.wjgnet.com/2150-5349/full/v17/i2/119778.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v17.i2.119778 |
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