6/26/2026 9:50:18 AM | Browse: 0 | Download: 0
| Publication Name | World Journal of Hepatology |
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| Manuscript ID | 119792 |
| Country | Saudi Arabia |
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| ISSN | 1948-5182 (online) |
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| Open Access | Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Basic Study | ||||||
| Article Title | Differential Impact of High-Fructose and Ethanol Diets on Early Steatohepatitis and Hepatic Melanocortin-4 Receptor Responses in Rats | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Salamah M Alwahsh, Min Xu, Maisa Nabulsi, Sabine Mihm, Faisal A Alzahrani and Giuliano Pasquale Ramadori | ||||||
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| Corresponding Author | Faisal A Alzahrani, PhD, Professor, Department of Biochemistry, Faculty of Science, Stem Cells Unit, King Fahd Medical Research Center, King Abdulaziz University, Abdullah Suliman Street, Jeddah 21589, Saudi Arabia. faahalzahrani@kau.edu.sa | ||||||
| Key Words | Metabolic dysfunction-associated steatotic liver disease; Fatty liver; Inflammation; Fructose; Alcohol | ||||||
| Core Tip | Modern dietary habits often combine high-fructose beverages with alcohol, yet their distinct hepatic effects remain poorly defined. Using controlled rat dietary models, this study demonstrates that a high-fructose diet primarily induces metabolic overload, endocrine dysregulation, visceral adiposity, and steatosis, whereas fructose combined with ethanol amplifies hepatocellular injury, inflammatory signaling, and regenerative activity. Multi-level analyses (qRT-PCR, Western blot, immunohistochemistry, and immunofluorescence) reveal dynamic hepatic melanocortin-4 receptor (MC4R) responses, including altered glycosylation and increased nuclear localization. These findings provide new insights into a potential peripheral adaptive role of MC4R in early steatohepatitis and highlight how distinct dietary stressors generate different pathogenic trajectories in metabolic dysfunction-associated steatotic liver disease (MASLD). | ||||||
| Publish Date | 2026-06-26 09:50 | ||||||
| Citation |
Alwahsh SM, Xu M, Nabulsi M, Mihm S, Alzahrani FA, Ramadori GP. Differential Impact of High-Fructose and Ethanol Diets on Early Steatohepatitis and Hepatic Melanocortin-4 Receptor Responses in Rats. World J Hepatol 2026; 18(6): 119792 |
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| URL | https://www.wjgnet.com/1948-5182/full/v18/i6/119792.htm | ||||||
| DOI | https://doi.org/10.4254/wjh.119792 |
| Full Article (PDF) | WJH-18-119792-with-cover.pdf |
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| The ARRIVE Guidelines | 119792-The-ARRIVE-Guidelines.pdf |
| Manuscript File | 119792_Auto_Edited_064939-YJP.docx |
| Answering Reviewers | 119792-answering-reviewers.pdf |
| Audio Core Tip | 119792-audio.mp3 |
| Biostatistics Review Certificate | 119792-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 119792-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 119792-copyright-assignment.pdf |
| Institutional Animal Care and Use Committee Approval Form or Document | 119792-institutional-animal-care-and-use-committee-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 119792-non-native-speakers.pdf |
| Supplementary Material | 119792-supplementary-material.pdf |
| Peer-review Report | 119792-peer-reviews.pdf |
| Scientific Misconduct Check | 119792-scientific-misconduct-check.png |
| Scientific Editor Work List | 119792-scientific-editor-work-list.pdf |
| CrossCheck Report | 119792-crosscheck-report.pdf |