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Articles Published Processes
6/26/2026 9:50:21 AM | Browse: 0 | Download: 0
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Received |
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2026-02-07 03:26 |
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Peer-Review Started |
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2026-02-07 03:27 |
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First Decision by Editorial Office Director |
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2026-02-28 06:53 |
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Return for Revision |
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2026-02-28 06:53 |
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Revised |
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2026-03-17 00:32 |
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Publication Fee Transferred |
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2026-04-08 17:02 |
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Second Decision by Editor |
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2026-05-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-26 08:31 |
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Articles in Press |
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2026-05-26 08:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-10 00:26 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Phase-dependent interpretation of quantitative hepatitis B surface antigen and hepatocellular carcinoma risk in chronic hepatitis B infection
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yazan Omari and Mohammad Almeqdadi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yazan Omari, MD, Internal Medicine, Henry Ford Health, 16001 West 9 Mile Road, Southfield, MI 48075, United States. yazanomari12@gmail.com |
| Key Words |
Quantitative hepatitis B surface antigen; Hepatitis B; Hepatocellular carcinoma; Disease phase; Hepatitis B virus integration; Risk stratification; Phase-dependent interpretation |
| Core Tip |
Quantitative hepatitis B surface antigen can serve as a complementary predictor of development of hepatocellular carcinoma among chronic hepatitis B patients. However, its interpretation is largely dependent on the phase of chronic hepatitis B at which it was measured. This phase-dependence arise from inherent differences in the pathophysiology of viral replication (from covalently closed circular DNA in early stages to integration-driven antigen production in later stages) and evolving host immune control. Clinically, quantitative hepatitis B surface antigen offers the most predictive value in hepatitis B e antigen negative patients with low viremia (< 2000 IU/mL). In this group, persistently elevated marker level (> 1000 IU/mL) can identify patients with significantly increased risk of developing hepatocellular carcinoma who warrant closer monitoring or earlier treatment discussion. Recognizing this in context is essential for appropriate clinical use. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Omari Y, Almeqdadi M. Phase-dependent interpretation of quantitative hepatitis B surface antigen and hepatocellular carcinoma risk in chronic hepatitis B infection. World J Hepatol 2026; 18(6): 119837
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/119837.htm |
| DOI |
https://doi.org/10.4254/wjh.119837 |
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