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Publication Name World Journal of Meta-Analysis
Manuscript ID 119849
Country Lebanon
Received
2026-02-07 03:17
Peer-Review Started
2026-02-07 03:17
First Decision by Editorial Office Director
2026-02-28 06:50
Return for Revision
2026-02-28 22:02
Revised
2026-03-08 20:40
Publication Fee Transferred
Second Decision by Editor
2026-03-19 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-19 09:51
Articles in Press
2026-03-19 09:51
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-29 05:23
Publish the Manuscript Online
2026-06-12 06:20
ISSN 2308-3840 (online)
Open Access Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Meta-Analysis
Article Title Glucagon-like peptide-1-based incretin agonists in obesity-related heart failure with preserved ejection fraction: A systematic review and meta-analysis
Manuscript Source Unsolicited Manuscript
All Author List Ehab Al Mashtoub, Ali Hteit, Anthony Bedran, Janette Al Banna, Charbel El Hachem, Nazih Obeid, Mostafa Msheik, Mohamad Tlais and Razan Abdulaal
ORCID
Author(s) ORCID Number
Mohamad Tlais http://orcid.org/0009-0008-5934-2212
Funding Agency and Grant Number
Corresponding Author Mohamad Tlais, MD, Cardiology, University of Balamand, Hazmieh, Beirut 1100, Beyrouth, Lebanon. mmtlaiss22@gmail.com
Key Words Heart failure with preserved ejection fraction; Obesity-related heart failure with preserved ejection fraction; Glucagon-like peptide-1 receptor agonists; Dual GIP/GLP-1 receptor agonist; Incretin agonists; Semaglutide; Tirzepatide; Weight loss; Meta-analysis; Systematic review
Core Tip Glucagon-like peptide-1 (GLP)-1-based incretin agonists, including semaglutide and the dual GIP/GLP-1 receptor agonist tirzepatide, produce consistent and clinically meaningful improvements in symptoms, functional capacity, and body weight in patients with obesity-related heart failure with preserved ejection fraction. Tirzepatide additionally reduced the composite of cardiovascular death or worsening heart failure events, establishing weight-centric pharmacotherapy as a promising disease-modifying strategy for this high-risk and previously treatment-resistant phenotype.
Publish Date 2026-06-12 06:20
Citation

Al Mashtoub E, Hteit A, Bedran A, Al Banna J, El Hachem C, Obeid N, Msheik M, Tlais M, Abdulaal R. Glucagon-like peptide-1-based incretin agonists in obesity-related heart failure with preserved ejection fraction: A systematic review and meta-analysis. World J Meta-Anal 2026; 14(2): 119849

URL https://www.wjgnet.com/2308-3840/full/v14/i2/119849.htm
DOI https://doi.org/10.13105/wjma.v14.i2.119849
Full Article (PDF) WJMA-14-119849-with-cover.pdf
PRISMA 2009 Checklist 119849-PRISMA-2009-Checklist.pdf
Manuscript File 119849_Auto_Edited_095039.docx
Answering Reviewers 119849-answering-reviewers.pdf
Audio Core Tip 119849-audio.mp3
Biostatistics Review Certificate 119849-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 119849-conflict-of-interest-statement.pdf
Copyright License Agreement 119849-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 119849-non-native-speakers.pdf
Supplementary Material 119849-supplementary-material.pdf
Peer-review Report 119849-peer-reviews.pdf
Scientific Misconduct Check 119849-scientific-misconduct-check.png
Scientific Editor Work List 119849-scientific-editor-work-list.pdf
CrossCheck Report 119849-crosscheck-report.pdf