Publication Name	World Journal of Nephrology
Manuscript ID	11989
Country	Japan

Received	2014-06-16 19:41
Peer-Review Started	2014-06-16 22:13
To Make the First Decision	2014-06-27 11:58
Return for Revision	2014-07-07 10:30
Revised	2014-07-15 16:29
Second Decision	2014-09-17 13:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-17 14:16
Articles in Press	2014-09-17 14:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-23 09:56
Publish the Manuscript Online	2014-11-07 16:40

ISSN	2220-6124 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Searching for a treatment for Alport syndrome using mouse models
Manuscript Source	Invited Manuscript
All Author List	Kan Katayama, Shinsuke Nomura, Karl Tryggvason and Masaaki Ito
Funding Agency and Grant Number
Corresponding Author	Kan Katayama, MD, PhD, Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. katayamk@clin.medic.mie-u.ac.jp
Key Words	Alport syndrome; Angiotensin-converting enzyme; Genetic; Hereditary nephritis; Pharmacological; Renal injury; Stem cell therapy
Core Tip	There is currently no curative treatment for Alport syndrome, a progressive hereditary nephritis. However, many drugs have been demonstrated to slow the progression of renal injury in Alport mouse models. Alport mice treated with vasopeptidase inhibitors or angiotensin-converting enzyme inhibitors showed a more than two-fold longer survival than untreated Alport mice. A human clinical trial of an angiotensin-converting enzyme inhibitor is currently in progress. Genetic approaches have been used to elucidate the pathogenesis of this progressive renal disease. Stem cell therapies were also attempted, with some beneficial effects; however, they need to be improved before being tested in clinical trials.
Publish Date	2014-11-07 16:40
Citation	Katayama K, Nomura S, Tryggvason K, Ito M. Searching for a treatment for Alport syndrome using mouse models. World J Nephrol 2014; 3(4): 230-236
URL	http://www.wjgnet.com/2220-6124/full/v3/i4/230.htm
DOI	http://dx.doi.org/10.5527/wjn.v3.i4.230

Full Article (PDF)	WJN-3-230.pdf
Full Article (Word)	WJN-3-230.doc
Manuscript File	11989-Review.doc
Answering Reviewers	11989-Answering reviewers.pdf
Copyright License Agreement	11989-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20140616160908.pdf
Peer-review Report	11989-Peer review(s).pdf
Scientific Misconduct Check	11989-CrossCheck.jpg
Scientific Editor Work List	11989-Scientific editor work list.pdf