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Articles Published Processes
7/24/2026 10:16:22 AM | Browse: 2 | Download: 1
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Received |
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2026-02-10 02:51 |
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Peer-Review Started |
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2026-02-10 02:53 |
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First Decision by Editorial Office Director |
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2026-02-14 07:59 |
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Return for Revision |
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2026-02-15 07:01 |
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Revised |
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2026-02-27 08:20 |
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Publication Fee Transferred |
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2026-03-02 00:09 |
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Second Decision by Editor |
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2026-03-27 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-03 07:02 |
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Articles in Press |
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2026-04-03 07:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-21 01:05 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Regulatory T cell-derived exosomes regulate β-catenin expression to promote the stem cell-like properties of hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Jun Tu, Yun-Qi Liu, Hong-Yang Cai, Yan-Yan Pan and Chang Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82303572 |
| Department of Science & Technology of Liaoning Province |
2024-MS-285 |
| Hospital Initiated Project of “Liaoning Province Key Specialty” |
2023SZ015 |
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| Corresponding Author |
Chang Liu, Affiliate Associate Professor, PhD, Central Laboratory, Central Hospital of Dalian University of Technology, No. 826 Southwest Road, Dalian 116033, Liaoning Province, China. liuch2024@dlut.edu.cn |
| Key Words |
Regulatory T cell; Exosome; Cancer stem cell; Tumor-initiating cell; Hepatocellular carcinoma |
| Core Tip |
In our previous study, we demonstrated that regulatory T (Treg) cells increase the population of tumor-initiating cells in hepatocellular carcinoma by suppressing forkhead box P3 and enhancing β-catenin expression. However, it remained unclear whether Treg cells exert these effects through exosomes and which specific components within Treg-derived exosomes are responsible. In this study, we revealed that exosomal long non-coding RNA Flicr, derived from Treg cells, suppresses forkhead box P3 and glycogen synthase kinase-3 beta expression and activates the Wnt/β-catenin signaling pathway, thereby promoting stem cell-like properties in hepatocellular carcinoma cells. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Tu YJ, Liu YQ, Cai HY, Pan YY, Liu C. Regulatory T cell-derived exosomes regulate β-catenin expression to promote the stem cell-like properties of hepatocellular carcinoma. World J Stem Cells 2026; 18(7): 119892
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/119892.htm |
| DOI |
https://doi.org/10.4252/wjsc.119892 |
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