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Articles Published Processes
7/24/2026 10:16:21 AM | Browse: 1 | Download: 0
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Received |
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2026-02-10 01:58 |
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Peer-Review Started |
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2026-02-10 01:59 |
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First Decision by Editorial Office Director |
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2026-02-27 08:57 |
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Return for Revision |
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2026-02-27 08:57 |
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Revised |
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2026-03-09 08:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-29 02:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 06:55 |
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Articles in Press |
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2026-06-09 06:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-21 01:02 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Opinion Review |
| Article Title |
Bone marrow niche adaptation, leukemic stem cell persistence, and therapeutic resistance in FLT3-mutated leukemia
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huai-Bin Zhang, Hui-Hui Jiang, Jian-Chuan Deng and Nan Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82500204 |
| Natural Science Foundation of Chongqing |
CSTB2025NSCQ-GPX1181 |
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| Corresponding Author |
Nan Zhang, Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing 400010, China. zhangnan@hospital.cqmu.edu.cn |
| Key Words |
FLT3 mutation; Acute myeloid leukemia; Bone marrow microenvironment; Leukemia stem cell; Therapeutic resistance |
| Core Tip |
FLT3-mutated leukemia remains clinically challenging because therapeutic resistance is driven not only by intrinsic oncogenic signaling, but also by adaptive interactions with the bone marrow microenvironment. This review highlights how stromal protection, chemokine-mediated retention, hypoxic support, metabolic rewiring, immune evasion, and leukemia stem cell persistence collectively promote treatment failure and relapse. It also summarizes current and emerging therapeutic strategies aimed at cotargeting FLT3 signaling, the supportive niche, and stem cell-related vulnerabilities. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Zhang HB, Jiang HH, Deng JC, Zhang N. Bone marrow niche adaptation, leukemic stem cell persistence, and therapeutic resistance in FLT3-mutated leukemia. World J Stem Cells 2026; 18(7): 119893
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/119893.htm |
| DOI |
https://doi.org/10.4252/wjsc.119893 |
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