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Articles Published Processes
7/24/2026 10:16:19 AM | Browse: 2 | Download: 0
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Received |
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2026-02-10 02:51 |
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Peer-Review Started |
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2026-02-10 02:53 |
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First Decision by Editorial Office Director |
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2026-02-28 06:41 |
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Return for Revision |
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2026-02-28 06:41 |
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Revised |
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2026-04-11 06:46 |
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Publication Fee Transferred |
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2026-04-22 02:38 |
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Second Decision by Editor |
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2026-05-29 09:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-04 08:56 |
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Articles in Press |
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2026-06-04 08:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-01 00:51 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Platelet-derived mitochondria transfer accelerates fracture healing by promoting osteogenic differentiation and metabolic reprogramming of adipose-derived stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhu Pan, Rui Zhang, Gai-Mei Du, Ji-Hai Yi, Jin Bao and Cai-Dong Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2024 Jiangsu Blood Transfusion Association Research Fund |
JSYK2024005 |
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| Corresponding Author |
Cai-Dong Liu, Department of Blood Transfusion, Nanjing First Hospital, No. 68 Changle Road, Qinhuai District, Nanjing 210006, Jiangsu Province, China. liucd2281@163.com |
| Key Words |
Adipose-derived stem cells; Platelet-derived mitochondria; Osteogenic differentiation; Glycolysis; Histone lactylation; Fracture healing; Metabolic reprogramming; Epigenetic regulation |
| Core Tip |
Platelets promote glycolysis and osteogenic differentiation of adipose-derived stem cells (ASCs) by transferring mitochondria. Mechanically, mitochondria facilitate H3K18 lactylation, thereby inducing transcription of AXIN2, BMPR1B, COL1A1, and OSTN. Moreover, platelet-derived mitochondria enhance the effect of ASCs on fracture healing through glycolysis. Collectively, platelet-derived mitochondria transfer promotes the lactylation of H3K18 through lactate produced by glycolysis, promotes the transcription of osteogenesis-related genes, thereby promoting the osteogenic differentiation of ASCs and then accelerating fracture healing. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Pan Z, Zhang R, Du GM, Yi JH, Bao J, Liu CD. Platelet-derived mitochondria transfer accelerates fracture healing by promoting osteogenic differentiation and metabolic reprogramming of adipose-derived stem cells. World J Stem Cells 2026; 18(7): 119895
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/119895.htm |
| DOI |
https://doi.org/10.4252/wjsc.119895 |
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