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Articles Published Processes
7/17/2026 8:23:32 AM | Browse: 2 | Download: 0
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Received |
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2026-02-10 10:01 |
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Peer-Review Started |
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2026-02-10 10:01 |
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First Decision by Editorial Office Director |
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2026-03-04 09:01 |
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Return for Revision |
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2026-03-04 09:01 |
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Revised |
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2026-03-17 15:57 |
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Publication Fee Transferred |
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2026-03-23 14:38 |
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Second Decision by Editor |
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2026-04-20 02:54 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-20 06:21 |
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Articles in Press |
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2026-04-20 06:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-13 01:08 |
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Publish the Manuscript Online |
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2026-07-17 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
γδ T cells exacerbate intestinal fibrosis in mice with experimental colitis via activation of the CD73-adenosine receptor-cyclic AMP signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Wei Dong, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Dong-Chun Liang, De-Ming Sun and Cheng Lan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81860102, 82060102 |
| Hainan Provincial Natural Science Foundation High-Level Talent Project |
821RC1116, 822RC818 |
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| Corresponding Author |
Cheng Lan, Chief Physician, MD, Professor, Department of Gastroenterology, Hainan General Hospital, Affiliated Hainan Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. lancheng71@163.com |
| Key Words |
Intestinal fibrosis; γδ T cells; CD73; Adenosine receptor; Cyclic AMP |
| Core Tip |
This study elucidated a critical pathogenic role for γδ T cells in driving intestinal fibrosis. Mechanistically, these cells promote fibrosis most likely by upregulating the CD73-adenosine receptor-cyclic AMP signaling pathway. Depletion of γδ T cells or pharmacological inhibition of CD73 attenuated fibrogenesis, as evidenced by reduced collagen deposition and profibrotic cytokine expression. Conversely, adoptive transfer of γδ T cells exacerbated disease severity. These findings nominate the γδ T cell-CD73-adenosine receptor-cyclic AMP pathway as a novel and promising therapeutic target for intestinal fibrosis. |
| Publish Date |
2026-07-17 08:23 |
| Citation |
Dong LW, Ma ZC, Fu J, Huang BL, Liu FJ, Liang DC, Sun DM, Lan C. γδ T cells exacerbate intestinal fibrosis in mice with experimental colitis via activation of the CD73-adenosine receptor-cyclic AMP signaling pathway. World J Gastroenterol 2026; 32(29): 119920
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i29/119920.htm |
| DOI |
https://doi.org/10.3748/wjg.119920 |
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