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Articles Published Processes
6/11/2026 11:23:56 AM | Browse: 0 | Download: 0
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Received |
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2026-02-12 00:51 |
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Peer-Review Started |
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2026-02-12 23:58 |
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First Decision by Editorial Office Director |
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2026-02-25 07:49 |
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Return for Revision |
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2026-02-25 07:49 |
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Revised |
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2026-03-08 16:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-06 03:20 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-06 06:41 |
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Articles in Press |
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2026-05-06 06:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-03 12:29 |
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Publish the Manuscript Online |
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2026-06-11 11:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Opinion Review |
| Article Title |
Hidden metabolic crisis in lean youth: Waist-to-height ratio uncovers endoplasmic reticulum stress-driven insulin resistance in platelets
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zeng-Gao Han, Yang Yang, Peng-Yan Huang, Min Yang, Guo-Dong Zhang, Xu Yang, Chen-Yu Song, Jing-Shun Lu and Kai-Yang Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kai-Yang Wang, Assistant Professor, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com |
| Key Words |
Insulin resistance; Waist-to-height ratio; Endoplasmic reticulum stress; Platelet; Body mass index; Adiposity; Metabolic syndrome; Adolescent |
| Core Tip |
The waist-to-height ratio, with a threshold of > 0.5, offers a simple yet powerful anthropometric tool to unmask hidden insulin resistance and cardiometabolic risk in metabolically unhealthy normal-weight youth - a population routinely missed by body mass index-centric screening. This paradigm shift is grounded in mechanistic links among visceral adiposity, systemic inflammation, and endoplasmic reticulum stress, with emerging evidence positioning platelets as accessible biosensors of endoplasmic reticulum stress. Integrating waist-to-height ratio into routine youth health assessments enables early, precise intervention and holds potential to curb the lifelong burden of metabolic disease. |
| Publish Date |
2026-06-11 11:23 |
| Citation |
Han ZG, Yang Y, Huang PY, Yang M, Zhang GD, Yang X, Song CY, Lu JS, Wang KY. Hidden metabolic crisis in lean youth: Waist-to-height ratio uncovers endoplasmic reticulum stress-driven insulin resistance in platelets. World J Diabetes 2026; 17(6): 119998
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i6/119998.htm |
| DOI |
https://doi.org/10.4239/wjd.119998 |
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