Publication Name	World Journal of Gastroenterology
Manuscript ID	12000
Country	China

Received	2014-06-17 09:34
Peer-Review Started	2014-06-17 20:12
To Make the First Decision	2014-08-06 17:26
Return for Revision	2014-08-15 16:51
Revised	2014-08-29 18:17
Second Decision	2014-11-27 12:59
Accepted by Journal Editor-in-Chief	2014-11-27 17:06
Accepted by Executive Editor-in-Chief	2014-12-08 15:55
Articles in Press	2014-12-08 17:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-12-23 08:28
Typeset the Manuscript	2015-02-26 09:42
Publish the Manuscript Online	2015-03-09 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Evaluation of changes of serum hepatitis B surface antigen from a different perspective
Manuscript Source	Unsolicited Manuscript
All Author List	Ze-Qian Wu, Lei Tan, Ting Liu, Zhi-Liang Gao and Wei-Min Ke
Funding Agency and Grant Number
Corresponding Author	Wei-Min Ke, MD, Professor, Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Topical Disease Control, Sun Yat-sen University, Ministry of Education, Shipai Road, Guangzhou 510630, Guangdong Province, China. tcl3626@gmail.com
Key Words	Serum hepatitis B surface antigen; Chronic hepatitis B; Hepatic parenchyma cell quantities; Liver inflammation grades; Hepatic fibrosis stages
Core Tip	Hepatitis B surface antigen (HBsAg)-negative chronic hepatitis B patients always feature increasing liver fibrosis and decreasing hepatic parenchyma cells. Does it influence the circulating HBsAg released into the serum? It requires research on the condition that the impact of fibrous volume on hepatic cell quantities should be deducted. It turns out that there were significant differences in serum HBsAg levels apportioned by the same hepatic cell quantities among different liver histological inflammation grades, as well as different hepatic fibrosis stages. In conclusion, although hepatitis B virus replication place - hepatic cell quantities - were shrinking while fibrosis progresses, its replication and expression became more active rather than declined or silenced.
Publish Date	2015-03-09 15:58
Citation	Wu ZQ, Tan L, Liu T, Gao ZL, Ke WM. Evaluation of changes of serum hepatitis B surface antigen from a different perspective. World J Gastroenterol 2015; 21(9): 2739-2745
URL	http://www.wjgnet.com/1007-9327/full/v21/i9/2739.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i9.2739

Full Article (PDF)	WJG-21-2739.pdf
Full Article (Word)	WJG-21-2739.doc
Manuscript File	12000-Review.doc
Answering Reviewers	12000-Answering reviewers.pdf
Copyright License Agreement	12000-Copyright assignmen.pdf
Peer-review Report	12000-Peer review(s).pdf
Scientific Misconduct Check	12000-CrossCheck.jpg
Scientific Editor Work List	12000-Scientific editor work list.pdf