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9/18/2026 3:45:43 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 120035
Country China
Received
2026-02-13 03:04
Peer-Review Started
2026-02-13 03:04
First Decision by Editorial Office Director
2026-03-02 09:06
Return for Revision
2026-03-02 09:06
Revised
2026-04-15 15:28
Publication Fee Transferred
Second Decision by Editor
2026-06-01 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-06-02 08:13
Articles in Press
2026-06-02 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-30 07:37
Publish the Manuscript Online
2026-09-18 03:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Opinion Review
Article Title Dual effects of a high-protein diet on metabolic dysfunction-associated steatotic liver disease: Basic research on precision clinical interventions  
Manuscript Source Invited Manuscript
All Author List Ya-Rong Ma, Wen-Long Miao, Na Li, Gui-Zhen Zhang and Zhi-Gang Ren
ORCID
Author(s) ORCID Number
Gui-Zhen Zhang http://orcid.org/0009-0008-3752-4648
Zhi-Gang Ren http://orcid.org/0000-0003-0798-3444
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 82470654
the Natural Science Foundation Key Project of Henan Province 232300421124
the Henan Zhongyuan Medical Science and Technology Innovation and Development Foundation ZYYC202301ZD
the Postdoctoral Fellowship Program of the China Postdoctoral Science Foundation GZC20232430
Corresponding Author Zhi-Gang Ren, MD, PhD, Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, No. 46 Jianshe East Road, Zhengzhou 450052, Henan Province, China. fccrenzg@zzu.edu.cn
Key Words High-protein diet; Metabolic dysfunction-associated steatotic liver disease; Precision nutrition; Intestinal microbiota; Plant-based protein
Core Tip A high-protein diet has dual effects on metabolic dysfunction-associated steatotic liver disease (MASLD), with protein source, intake level, and host metabolic phenotype serving as key regulators. Although previous studies have established a framework involving the gut–liver axis and amino acid pathways, gaps persist in causal mechanisms, intake thresholds, and clinical translation of multiomic findings. Future work should prioritize validating plant-based protein bioactivities, developing personalized algorithms that integrate host–microbiota interactions, and conducting long-term randomized controlled trials for precise MASLD dietary guidance.  
Publish Date 2026-09-18 03:45
Citation

Ma YR, Miao WL, Li N, Zhang GZ, Ren ZG. Dual effects of a high-protein diet on metabolic dysfunction-associated steatotic liver disease: Basic research on precision clinical interventions. World J Gastroenterol 2026; 32(41): 120035

URL https://www.wjgnet.com/1007-9327/full/v32/i41/120035.htm
DOI https://doi.org/10.3748/wjg.120035
Full Article (PDF) WJG-32-120035-with-cover.pdf
Manuscript File 120035_Auto_Edited_011642.docx
Answering Reviewers 120035-answering-reviewers.pdf
Audio Core Tip 120035-audio.m4a
Conflict-of-Interest Disclosure Form 120035-conflict-of-interest-statement.pdf
Copyright License Agreement 120035-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 120035-non-native-speakers.pdf
Peer-review Report 120035-peer-reviews.pdf
Scientific Misconduct Check 120035-scientific-misconduct-check.png
CrossCheck Report 120035-crosscheck-report.pdf