| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Immunometabolic drivers of metabolic dysfunction-associated steatotic liver disease in non-obese people living with human immunodeficiency virus
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fei Ji, Li-Fan Zhang, Yang Gui, Zhen-Hong Qi, Yang Han, Na Su, Qing Zhang, Yan-Ling Li, Wei Zhao, Wei Lyu and Meng Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key RD Program of China |
No. 2023YFC2411705 |
| National Natural Science Foundation of China |
No. U22A2023 |
| National Natural Science Foundation of China |
No. 62325112 |
| CAMS Innovation Fund for Medical Sciences |
No. 2025-I2M-XHJC-003 |
| PUMCH Talent Development Support Program |
No. ULJ04684 |
| National High-Level Hospital Clinical Research Funding |
No. 2025-PUMCH-C-052 |
| National High-Level Hospital Clinical Research Funding |
No. 2022-PUMCH-D-008 |
|
| Corresponding Author |
Meng Yang, MD, PhD, Professor, Department of Ultrasonography, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. yangmeng_pumch@126.com |
| Key Words |
Human immunodeficiency virus; Metabolic dysfunction-associated steatotic liver disease; Integrase strand transfer inhibitors; Antiretroviral therapy; Transient elastography |
| Core Tip |
In virologically suppressed people living with human immunodeficiency virus (PLWH), metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent even in non-obese individuals. We report a paradoxical finding: A higher cluster of differentiation (CD) 4/CD8 ratio, a marker of favorable immune recovery, was independently associated with increased MASLD risk in non-obese PLWH (odds ratio = 8.55). This challenges the view that immune reconstitution is the sole therapeutic endpoint. Instead, metabolic risk stratification including routine steatosis assessment is warranted even in immunologically favorable, non-obese individuals. Integrase strand transfer inhibitors-based antiretroviral therapy demonstrated short-term hepatic safety. |
| Publish Date |
2026-09-18 03:45 |
| Citation |
Ji F, Zhang LF, Gui Y, Qi ZH, Han Y, Su N, Zhang Q, Li YL, Zhao W, Lyu W, Yang M. Immunometabolic drivers of metabolic dysfunction-associated steatotic liver disease in non-obese people living with human immunodeficiency virus. World J Gastroenterol 2026; 32(41): 120036
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i41/120036.htm |
| DOI |
https://doi.org/10.3748/wjg.120036 |
