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8/13/2026 7:25:29 AM | Browse: 2 | Download: 0
Publication Name World Journal of Nephrology
Manuscript ID 120037
Country Egypt
Received
2026-02-13 02:35
Peer-Review Started
2026-02-13 02:35
First Decision by Editorial Office Director
2026-03-03 09:30
Return for Revision
2026-03-03 09:30
Revised
2026-04-04 13:59
Publication Fee Transferred
2026-05-01 11:34
Second Decision by Editor
2026-07-02 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-07-02 08:09
Articles in Press
2026-07-02 08:09
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-16 10:06
Publish the Manuscript Online
2026-08-13 07:25
ISSN 2220-6124 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Clinical Neurology
Manuscript Type Randomized Controlled Trial
Article Title Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label
Manuscript Source Unsolicited Manuscript
All Author List Ashraf Hassan Abd El Mobdy, Hayam Ahmed Hebah, Mohammed Ali Ezzat, Basant Abdelkarim Eid Mohamed and Fatma Abdelrahman Ahmed
ORCID
Author(s) ORCID Number
Ashraf Hassan Abd El Mobdy http://orcid.org/0009-0001-4232-7808
Funding Agency and Grant Number
Corresponding Author Ashraf Hassan Abd El Mobdy, Internal Medicine and Nephrology, Faculty of Medicine, Ain shams University, Cairo, Egypt., Ahmed Fakhry Street, Nasr City, Cairo, Egypt, Cairo 31511, Al Qāhirah, Egypt. ashrafnephro@med.asu.edu.eg
Key Words Pentoxifylline; Inflammatory marker; Non-diabetic; Chronic kidney disease; Tumour necrosis factor-alpha
Core Tip This randomized controlled study evaluated the effect of pentoxifylline (PTX) on inflammation and disease progression in non-diabetic chronic kidney disease (CKD) stages 3-4. Adding PTX to standard therapy significantly reduced C-reactive protein and proteinuria compared with standard treatment alone. Changes in tumour necrosis factor-alpha were inversely correlated with estimated glomerular filtration rate and urinary protein-to-creatinine ratio, highlighting a link between inflammation and renal function decline. PTX may offer additional anti-inflammatory and renoprotective benefits in non-diabetic CKD.
Publish Date 2026-08-13 07:25
Citation

Abd El Mobdy AH, Hebah HA, Ezzat MA, Eid Mohamed BA, Ahmed FA. Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label. World J Nephrol 2026; 15(3): 120037

URL https://www.wjgnet.com/2220-6124/full/v15/i3/120037.htm
DOI https://doi.org/10.5527/wjn.120037
Full Article (PDF) WJN-15-120037-with-cover.pdf
CONSORT 2010 Statement 120037-CONSORT-2010-statement.pdf
Manuscript File 120037_Auto_Edited_083636.docx
Answering Reviewers 120037-answering-reviewers.pdf
Audio Core Tip 120037-audio.ogg
Biostatistics Review Certificate 120037-biostatistics-statement.pdf
Clinical Trial Registration Statement 120037-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 120037-conflict-of-interest-statement.pdf
Copyright License Agreement 120037-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 120037-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 120037-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 120037-non-native-speakers.pdf
Peer-review Report 120037-peer-reviews.pdf
Scientific Misconduct Check 120037-scientific-misconduct-check.png
Scientific Editor Work List 120037-scientific-editor-work-list.pdf
CrossCheck Report 120037-crosscheck-report.pdf