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Articles Published Processes
6/18/2026 7:52:56 AM | Browse: 1 | Download: 11
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Received |
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2026-02-13 01:52 |
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Peer-Review Started |
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2026-02-13 01:52 |
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First Decision by Editorial Office Director |
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2026-02-26 07:29 |
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Return for Revision |
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2026-02-26 07:29 |
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Revised |
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2026-03-08 11:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-14 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-14 10:05 |
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Articles in Press |
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2026-04-14 10:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-28 08:17 |
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Publish the Manuscript Online |
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2026-06-18 07:52 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdellatif Bouayad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Hay al Hikma, Oujda 4867, Oriental, Morocco. abdellatifbouayad@hotmail.fr |
| Key Words |
Soluble human leukocyte antigen-G; Virus-associated cancers; Immune escape; Diagnostic biomarker; Prognostic biomarker; Immune evasion |
| Core Tip |
Increased soluble human leukocyte antigen-G (sHLA-G) levels are consistently associated with poor prognosis in hepatitis C virus/hepatitis B virus -related hepatocellular carcinoma and human papillomavirus-driven cervical cancer, underscoring its potential as a diagnostic and prognostic biomarker. High-risk human papillomavirus oncoproteins (E6 and E7) and hepatitis C virus proteins (core protein and nonstructural protein 3) may contribute to increased sHLA-G levels through cytokine-mediated immunosuppressive signalling pathways. The mechanisms by which sHLA-G-immunoglobulin-like transcript 2/immunoglobulin-like transcript 4 interactions modulate immune suppression in these virus-driven cancers remain incompletely understood. sHLA-G isoforms are primarily detected in plasma and other biological fluids using sandwich enzyme-linked immunosorbent assays, providing a reliable method for both clinical and research applications. |
| Publish Date |
2026-06-18 07:52 |
| Citation |
Bouayad A. Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview. World J Virol 2026; 15(2): 120048
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| URL |
https://www.wjgnet.com/2220-3249/full/v15/i2/120048.htm |
| DOI |
https://doi.org/10.5501/wjv.v15.i2.120048 |
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