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Articles Published Processes
8/3/2026 1:23:52 AM | Browse: 2 | Download: 0
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Received |
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2026-02-14 02:34 |
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Peer-Review Started |
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2026-02-14 02:35 |
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First Decision by Editorial Office Director |
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2026-02-25 08:02 |
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Return for Revision |
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2026-02-25 08:02 |
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Revised |
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2026-03-10 07:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-14 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-14 06:52 |
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Articles in Press |
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2026-05-14 06:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-23 03:51 |
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Publish the Manuscript Online |
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2026-08-03 01:23 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
James Guoxian Huang, Carina Jing-Xuan Tay, Marion Margaret Aw, Yung-Seng Lee and Delicia Shu-Qin Ooi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Exxon-Mobil National University Singapore Research Fellowship for Clinicians |
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| Corresponding Author |
James Guoxian Huang, Assistant Professor, Department of Paediatrics, Khoo Teck Puat - National University Children’s Medical Institute, National University Health System, 1E Kent Ridge Road, National University Health System Tower Block, Level 12, Singapore 119228, Singapore. paehgj@nus.edu.sg |
| Key Words |
Inflammatory bowel disease; Pediatrics; Metagenomic; Gut microbiome; Microbial shift; Functional shift |
| Core Tip |
Using a longitudinal paired design, this paediatric inflammatory bowel disease metagenomic study shows that transition from active disease to remission is marked by a distinct gut microbiome with functional relevance. Remission was associated with enrichment of beneficial taxa (Anaerostipes hadrus, Bifidobacterium spp., Faecalibacterium prausnitzii, Lactobacillus gasseri) and metabolic pathways supporting short-chain fatty acid production, epithelial barrier repair, and immune modulation, whereas flare was dominated by Klebsiella pneumoniae. These findings highlight microbiome-derived functional pathways as promising targets for non-invasive biomarkers and microbiome-based therapeutic strategies to sustain remission in paediatric inflammatory bowel disease. |
| Publish Date |
2026-08-03 01:23 |
| Citation |
Huang JG, Tay CJX, Aw MM, Lee YS, Ooi DSQ. Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease. World J Clin Pediatr 2026; 15(3): 120066
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i3/120066.htm |
| DOI |
https://doi.org/10.5409/wjcp.120066 |
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