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Articles Published Processes
10/21/2026 2:09:40 AM | Browse: 2 | Download: 0
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Received |
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2026-02-14 01:58 |
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Peer-Review Started |
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2026-02-14 02:01 |
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First Decision by Editorial Office Director |
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2026-02-26 07:27 |
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Return for Revision |
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2026-02-26 07:27 |
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Revised |
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2026-03-06 18:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-18 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-18 08:47 |
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Articles in Press |
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2026-05-18 08:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-15 10:04 |
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Publish the Manuscript Online |
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2026-10-21 02:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Systemic inflammation in metabolic dysfunction-associated steatotic liver disease: Biological relevance and diagnostic limits
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mariana M Ramírez-Mejía and Nahum Méndez-Sánchez |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nahum Méndez-Sánchez, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Colonia Toriello Guerra, Mexico City 14050, Mexico. nmendez@medicasur.org.mx |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Systemic inflammation; Liver fibrosis; C-reactive protein; Biological relevance; Diagnostic limit |
| Core Tip |
Several markers have been developed to assess systemic inflammation in metabolic dysfunction-associated steatotic liver disease, including blood cell-derived indices and C-reactive protein. Yet, a statistical association with fibrosis does not make them clinically useful. Duarte et al confirm this using National Health and Nutrition Examination Survey data. Although indices such as the neutrophil-to-lymphocyte ratio and systemic inflammatory response index are associated with fibrosis, their discriminatory power is limited. C-reactive protein performs only slightly better. This suggests that inflammatory markers should be considered contextual risk modifiers. Not standalone diagnostic tools for fibrosis detection. Future strategies should prioritize biomarkers that more directly capture fibrogenic activity. |
| Publish Date |
2026-10-21 02:09 |
| Citation |
Ramírez-Mejía MM, Méndez-Sánchez N. Systemic inflammation in metabolic dysfunction-associated steatotic liver disease: Biological relevance and diagnostic limits. World J Hepatol 2026; 18(10): 120087
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i10/120087.htm |
| DOI |
https://doi.org/10.4254/wjh.120087 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
