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8/3/2026 1:23:51 AM | Browse: 2 | Download: 0
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 120090
Country Egypt
Received
2026-02-14 00:42
Peer-Review Started
2026-02-14 01:45
First Decision by Editorial Office Director
2026-03-03 09:30
Return for Revision
2026-03-03 09:30
Revised
2026-03-16 16:07
Publication Fee Transferred
Second Decision by Editor
2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-15 07:06
Articles in Press
2026-05-15 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-16 02:58
Publish the Manuscript Online
2026-08-03 01:23
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Prospective Study
Article Title Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis
Manuscript Source Invited Manuscript
All Author List Mohammed F Kasem, Ragia M Said, Doaa R Dahshan, Samar H Elhadedy, Noha R Mohammed and Noha U Hashem
ORCID
Author(s) ORCID Number
Ragia M Said http://orcid.org/0000-0002-0067-5222
Noha U Hashem http://orcid.org/0000-0003-2548-0349
Funding Agency and Grant Number
Corresponding Author Ragia M Said, Professor, Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University, 38 Abbassia Square, Next to Al-Nour Mosque, Cairo 1181, Egypt. ragia_marei@med.asu.edu.eg
Key Words Soluble intercellular adhesion molecule-1; Hemodialysis; Online hemodiafiltration; Chronic kidney disease; Low-flux hemodialysis; High-flux hemodialysis
Core Tip Children on chronic hemodialysis (HD) are exposed to persistent inflammation, which contributes to endothelial activation and cardiovascular risk. The type of dialysis modality may influence this inflammatory burden. This study evaluates the effect of low-flux HD, high-flux HD, and online hemodiafiltration (OL-HDF) on circulating intercellular adhesion molecule-1 (ICAM-1), a marker of endothelial activation, in pediatric patients. Low-flux HD increased post-session soluble ICAM-1 levels, suggesting dialysis-related endothelial injury, whereas high-flux HD and OL-HDF significantly reduced its levels, with OL-HDF normalizing ICAM-1 to values comparable to healthy controls. These findings suggest that selecting more biocompatible and high-efficiency dialysis modalities may help mitigate dialysis-related inflammation and potentially reduce long-term endothelial activation in pediatric HD patients.
Publish Date 2026-08-03 01:23
Citation

Kasem MF, Said RM, Dahshan DR, Elhadedy SH, Mohammed NR, Hashem NU. Modality matters: Effect of dialysis modality on soluble intercellular adhesion molecule-1 in children on regular hemodialysis. World J Clin Pediatr 2026; 15(3): 120090

URL https://www.wjgnet.com/2219-2808/full/v15/i3/120090.htm
DOI https://doi.org/10.5409/wjcp.120090
Full Article (PDF) WJCP-15-120090-with-cover.pdf
CONSORT 2010 Statement 120090-CONSORT-2010-statement.pdf
Manuscript File 120090_Auto_Edited_005631.docx
Answering Reviewers 120090-answering-reviewers.pdf
Audio Core Tip 120090-audio.mp3
Biostatistics Review Certificate 120090-biostatistics-statement.pdf
Clinical Trial Registration Statement 120090-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form 120090-conflict-of-interest-statement.pdf
Copyright License Agreement 120090-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 120090-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 120090-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 120090-non-native-speakers.pdf
Peer-review Report 120090-peer-reviews.pdf
Scientific Misconduct Check 120090-scientific-misconduct-check.png
Scientific Editor Work List 120090-scientific-editor-work-list.pdf
CrossCheck Report 120090-crosscheck-report.pdf