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Articles Published Processes
6/26/2026 9:50:20 AM | Browse: 0 | Download: 0
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Received |
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2026-02-26 03:15 |
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Peer-Review Started |
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2026-02-26 03:17 |
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First Decision by Editorial Office Director |
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2026-03-20 11:12 |
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Return for Revision |
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2026-03-20 18:31 |
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Revised |
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2026-04-12 21:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-13 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-13 07:16 |
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Articles in Press |
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2026-05-13 07:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-15 09:14 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Evaluation of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tian-Tian Chen, Hao-Xian Gou and Zhu-Lin Luo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhu-Lin Luo, Professor, Department of College of Medicine, Southwest Jiaotong University, No. 111 North Section 1, Second Ring Road, Chengdu 610031, Sichuan Province, China. lzl810130@163.com |
| Key Words |
Sonic hedgehog; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Ballooned hepatocytes; Liver fibrosis |
| Core Tip |
Sonic hedgehog homolog (SHH) is specifically expressed in ballooned hepatocytes and can be detected by immunohistochemistry. SHH staining may improve the consistency of ballooned hepatocyte interpretation and is associated with the severity of metabolic dysfunction-associated steatohepatitis. However, current evidence primarily comes from single-center retrospective studies. SHH immunohistochemistry is a promising adjunctive diagnostic tool, but multicenter prospective validation is still required before routine clinical application. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Chen TT, Gou HX, Luo ZL. Evaluation of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Hepatol 2026; 18(6): 120134
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/120134.htm |
| DOI |
https://doi.org/10.4254/wjh.120134 |
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