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Publication Name World Journal of Cardiology
Manuscript ID 120150
Country Greece
Received
2026-02-24 07:32
Peer-Review Started
2026-02-24 07:32
First Decision by Editorial Office Director
2026-03-20 10:45
Return for Revision
2026-03-20 10:45
Revised
2026-04-10 16:51
Publication Fee Transferred
Second Decision by Editor
2026-05-13 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-13 07:43
Articles in Press
2026-05-13 07:43
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-06 02:50
Publish the Manuscript Online
2026-08-26 05:34
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Editorial
Article Title When coronary spasm reflects systemic vascular disease: Prognostic insights from endothelial dysfunction
Manuscript Source Invited Manuscript
All Author List Nikolaos Ktenopoulos, Nikias Milaras, Anastasios Apostolos, Konstantinos Tsioufis, Konstantinos Toutouzas and Skevos Sideris
ORCID
Author(s) ORCID Number
Nikolaos Ktenopoulos http://orcid.org/0000-0002-0995-7015
Nikias Milaras http://orcid.org/0000-0001-7312-0976
Konstantinos Tsioufis http://orcid.org/0000-0002-7636-6725
Skevos Sideris http://orcid.org/0000-0003-3165-224X
Funding Agency and Grant Number
Corresponding Author Nikias Milaras, MD, Department of Cardiology, "Hippokration" General Hospital, Vasilisis Sofias 14, Athens 11527, Greece. nikiasmilaras@gmail.com
Key Words Vasospastic angina; Endothelial dysfunction; Flow-mediated dilation; Coronary spasm; Prognosis; Risk stratification; Microvascular dysfunction
Core Tip In patients with vasospastic angina, impaired brachial artery flow-mediated dilation independently predicts adverse cardiovascular events and outperforms conventional angiographic spasm markers. These data support the concept that coronary spasm reflects systemic endothelial pathology rather than isolated epicardial hyperreactivity, highlighting the potential role of endothelial function testing in clinical risk stratification.
Publish Date 2026-08-26 05:34
Citation

Ktenopoulos N, Milaras N, Apostolos A, Tsioufis K, Toutouzas K, Sideris S. When coronary spasm reflects systemic vascular disease: Prognostic insights from endothelial dysfunction. World J Cardiol 2026; 18(8): 120150

URL https://www.wjgnet.com/1949-8462/full/v18/i8/120150.htm
DOI https://doi.org/10.4330/wjc.120150
Full Article (PDF) WJC-18-120150-with-cover.pdf
Manuscript File 120150_Auto_Edited_005817.docx
Answering Reviewers 120150-answering-reviewers.pdf
Audio Core Tip 120150-audio.mp3
Conflict-of-Interest Disclosure Form 120150-conflict-of-interest-statement.pdf
Copyright License Agreement 120150-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 120150-non-native-speakers.pdf
Peer-review Report 120150-peer-reviews.pdf
Scientific Misconduct Check 120150-scientific-misconduct-check.png
CrossCheck Report 120150-crosscheck-report.pdf