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Articles Published Processes
9/9/2026 9:45:08 AM | Browse: 1 | Download: 0
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Received |
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2026-02-24 03:49 |
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Peer-Review Started |
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2026-02-24 03:50 |
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First Decision by Editorial Office Director |
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2026-03-12 07:58 |
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Return for Revision |
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2026-03-12 07:58 |
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Revised |
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2026-04-06 09:16 |
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Publication Fee Transferred |
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2026-04-08 15:54 |
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Second Decision by Editor |
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2026-05-07 03:22 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-07 08:16 |
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Articles in Press |
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2026-05-07 08:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-24 00:29 |
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Publish the Manuscript Online |
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2026-09-09 09:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Yuan Ren, Hong-Yan Zhang, Chen-Xi Xie, Geng-Ping Zhou, Peng-Yu Chen, Hao Yuan, Kai Zhang, Yang Xu, Yang-Yang Wang, Tai-Yang Chen, Qing-Shan Li and Hai-Bo Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Young and Middle-aged Health Science and Technology Innovation Leading Talents Training Project |
YXKC2022002 |
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| Corresponding Author |
Hai-Bo Yu, PhD, Hepatobiliary and Pancreatic Surgery, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou, 450003, China, Zhengzhou 450003, Henan, China. yhb2101661@zzu.edu.cn |
| Key Words |
Cholangiocarcinoma; IQGAP1; MCM3; Nrf2; Apoptosis |
| Core Tip |
This study reveals for the first time that IQGAP1 drives cholangiocarcinoma progression by recruiting ubiquitin-specific peptidase 28 to stabilize MCM3 protein, inhibiting its ubiquitination. This stabilization activates the Nrf2 pathway, alleviating oxidative stress and suppressing apoptosis, thereby promoting tumor cell survival and growth. Inhibition of MCM3 reverses these effects. The findings identify IQGAP1 as a key regulator of the MCM3/Nrf2 axis and a promising therapeutic target. |
| Publish Date |
2026-09-09 09:45 |
| Citation |
Ren ZY, Zhang HY, Xie CX, Zhou GP, Chen PY, Yuan H, Zhang K, Xu Y, Wang YY, Chen TY, Li QS, Yu HB. IQGAP1 promotes tumor progression by stabilizing MCM3/Nrf2 in cholangiocarcinoma. World J Gastrointest Oncol 2026; 18(9): 120170
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i9/120170.htm |
| DOI |
https://doi.org/10.4251/wjgo.120170 |
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