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Publication Name World Journal of Cardiology
Manuscript ID 120186
Country Russia
Received
2026-02-28 02:06
Peer-Review Started
2026-02-28 02:06
First Decision by Editorial Office Director
2026-04-04 02:27
Return for Revision
2026-04-04 02:27
Revised
2026-04-21 17:59
Publication Fee Transferred
Second Decision by Editor
2026-05-06 03:17
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-06 07:44
Articles in Press
2026-05-06 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-10 00:18
Publish the Manuscript Online
2026-06-18 09:51
ISSN 1949-8462 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Systematic Reviews
Article Title Anticoagulants vs thrombolytic therapy for the management of right heart thrombus in pulmonary embolism: A systematic review
Manuscript Source Invited Manuscript
All Author List Kristina G Pereverzeva, Sergey S Yakushin and Natalia N Peregudova
ORCID
Author(s) ORCID Number
Kristina G Pereverzeva http://orcid.org/0000-0001-6141-8994
Sergey S Yakushin http://orcid.org/0000-0002-1394-3791
Natalia N Peregudova http://orcid.org/0000-0001-6177-1405
Funding Agency and Grant Number
Corresponding Author Sergey S Yakushin, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, 96 Stroykova Street, Ryazan 390026, Russia. s.yakushin@rzgmu.ru
Key Words Right heart thrombi; Pulmonary embolism; Thrombolytic therapy; Anticoagulants; Mortality; Heparin; Hemodynamic instability
Core Tip Management of patients with right heart thrombi in pulmonary embolism (PE) remains challenging. This meta-analysis of 205 patients did not reveal a significant advantage of routine thrombolytic therapy over isolated anticoagulation in reducing mortality. Our data do not support universal use of either strategy. Treatment decisions should be individualized, and clinicians should follow current guidelines, which recommend thrombolysis for hemodynamically unstable patients with massive PE.
Publish Date 2026-06-18 09:51
Citation

Pereverzeva KG, Yakushin SS, Peregudova NN. Anticoagulants vs thrombolytic therapy for the management of right heart thrombus in pulmonary embolism: A systematic review. World J Cardiol 2026; 18(6): 120186

URL https://www.wjgnet.com/1949-8462/full/v18/i6/120186.htm
DOI https://doi.org/10.4330/wjc.120186
Full Article (PDF) WJC-18-120186-with-cover.pdf
PRISMA 2009 Checklist 120186-PRISMA-2009-Checklist.pdf
Manuscript File 120186_Auto_Edited_070138.docx
Answering Reviewers 120186-answering-reviewers.pdf
Audio Core Tip 120186-audio.mp3
Biostatistics Review Certificate 120186-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 120186-conflict-of-interest-statement.pdf
Copyright License Agreement 120186-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 120186-non-native-speakers.pdf
Supplementary Material 120186-supplementary-material.pdf
Peer-review Report 120186-peer-reviews.pdf
Scientific Misconduct Check 120186-scientific-misconduct-check.png
Scientific Editor Work List 120186-scientific-editor-work-list.pdf
CrossCheck Report 120186-crosscheck-report.pdf