BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/22/2026 8:40:59 AM | Browse: 0 | Download: 0
 |
Received |
|
2026-02-24 02:52 |
|
Peer-Review Started |
|
2026-02-24 02:52 |
|
First Decision by Editorial Office Director |
|
2026-03-27 10:21 |
|
Return for Revision |
|
2026-03-27 10:21 |
|
Revised |
|
2026-04-22 09:23 |
|
Publication Fee Transferred |
|
2026-04-29 10:29 |
|
Second Decision by Editor |
|
2026-05-27 02:43 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-05-27 05:45 |
|
Articles in Press |
|
2026-05-27 05:45 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-06-04 12:02 |
|
Publish the Manuscript Online |
|
2026-06-22 08:40 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Compound Muji Granules enhances cisplatin efficacy against alpha-fetoprotein-producing gastric cancer by suppressing epidermal growth factor receptor signaling
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Li, Li Wang, Sen Zuo, Wen-Ting He and Tong Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Xinjiang Uygur Autonomous Region |
No. 2022D01C561 |
|
| Corresponding Author |
Tong Zhang, Department of Oncology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, o. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. ashtray45671@outlook.com |
| Key Words |
Compound Muji Granules; Alpha-fetoprotein-producing gastric cancer; Cisplatin; Epidermal growth factor receptor-phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin pathway; FU97 cells |
| Core Tip |
Compound Muji Granules (CMG) markedly inhibited proliferation, migration, and invasion of alpha-fetoprotein (AFP)-producing gastric cancer FU97 cells, reduced AFP secretion, and induced G0/G1 arrest and apoptosis. Notably, CMG combined with cisplatin produced stronger growth inhibition and pro-apoptotic effects than either agent alone. Network pharmacology and molecular docking identified epidermal growth factor receptor (EGFR) as a key CMG target, and quantitative real-time polymerase chain reaction/Western blotting confirmed that the combination suppresses the EGFR-phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin pathway at both messenger RNA and protein levels. Importantly, the antitumor activity of CMG plus cisplatin persisted in an EGFR-driven FU97 model, supporting CMG as a potential chemosensitizer for AFP-producing gastric cancer. |
| Publish Date |
2026-06-22 08:40 |
| Citation |
Li H, Wang L, Zuo S, He WT, Zhang T. Compound Muji Granules enhances cisplatin efficacy against alpha-fetoprotein-producing gastric cancer by suppressing epidermal growth factor receptor signaling. World J Clin Oncol 2026; 17(6): 120188
|
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i6/120188.htm |
| DOI |
https://doi.org/10.5306/wjco.120188 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
