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Articles Published Processes
7/14/2026 5:50:20 AM | Browse: 1 | Download: 0
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Received |
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2026-02-24 07:12 |
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Peer-Review Started |
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2026-02-24 07:13 |
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First Decision by Editorial Office Director |
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2026-03-05 09:38 |
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Return for Revision |
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2026-03-05 09:38 |
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Revised |
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2026-03-08 13:18 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-26 07:58 |
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Articles in Press |
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2026-05-26 07:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-07 03:12 |
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Publish the Manuscript Online |
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2026-07-14 05:50 |
| ISSN |
2218-5836 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Observational Study |
| Article Title |
MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vijetha Gunamala, Rajeswary Hari, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com |
| Key Words |
MicroRNA-26a2; MicroRNA-26a5; NF κB; MMP-13; Osteoarthritis |
| Core Tip |
MiR 26a5, identified as a stage-specific biomarker for osteoarthritis of the knee (KOA), has its levels inversely correlated with the NF-κB, COX 2, MMP 13 and NOS2 expression. In contrast to lowly involved miR 26a2, miR 26a5 protects against inflammation-induced cartilage degradation. Its loss of function speeds up the disease process, highlighting its therapeutic potential and utility in measuring the level of KOA, despite small sample sizes and short-term studies. |
| Publish Date |
2026-07-14 05:50 |
| Citation |
Gunamala V, Hari R, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. MiR 26a as a stage-dependent biomarker and therapeutic regulator of inflammation in knee osteoarthritis. World J Orthop 2026; 17(7): 120195
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| URL |
https://www.wjgnet.com/2218-5836/full/v17/i7/120195.htm |
| DOI |
https://doi.org/10.5312/wjo.120195 |
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