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Articles Published Processes
8/20/2026 6:54:17 AM | Browse: 1 | Download: 0
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Received |
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2026-02-24 01:20 |
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Peer-Review Started |
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2026-02-24 01:22 |
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First Decision by Editorial Office Director |
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2026-03-13 09:10 |
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Return for Revision |
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2026-03-13 09:10 |
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Revised |
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2026-04-08 09:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-12 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-12 11:13 |
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Articles in Press |
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2026-05-12 11:13 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-14 01:19 |
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Publish the Manuscript Online |
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2026-08-20 06:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Opinion Review |
| Article Title |
Maximizing stem cell yield from limited adipose tissue: A novel two-step digestion approach and future artificial intelligence-integrated perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Fan Wu, Xu Jiang, Jian-Guang Zhang and Wei Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei Zhang, PhD, Postdoc, Doctoral Workstation, Guangdong Eco-Engineering Polytechnic, No. 297 Guangshan First Road, Tianhe District, Guangzhou 510520, Guangdong Province, China. zw0915@163.com |
| Key Words |
Stromal vascular fraction; Adipose-derived stem cells; Enzymatic digestion; Cell yield; Regenerative medicine; Pediatric applications; Artificial intelligence |
| Core Tip |
The residual adipose tissue typically discarded after conventional enzymatic digestion contains viable and functionally-potent regenerative cells. The second digestion step yielded stromal vascular fraction 2, which exhibited high clonogenic potential. Although promising, the study’s generalizability is limited by its small sample size and lack of donor diversity. This review critically evaluates the methodology, discusses the impact of donor variability and enzyme lots on reproducibility, and proposes an artificial-intelligence-driven framework for personalizing digestion protocols. These insights aim to accelerate the clinical adoption and optimization of this valuable technique. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Wu YF, Jiang X, Zhang JG, Zhang W. Maximizing stem cell yield from limited adipose tissue: A novel two-step digestion approach and future artificial intelligence-integrated perspectives. World J Stem Cells 2026; 18(8): 120206
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/120206.htm |
| DOI |
https://doi.org/10.4252/wjsc.120206 |
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