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Articles Published Processes
8/7/2026 9:40:18 AM | Browse: 1 | Download: 0
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Received |
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2026-02-24 01:19 |
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Peer-Review Started |
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2026-02-24 01:22 |
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First Decision by Editorial Office Director |
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2026-03-06 08:36 |
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Return for Revision |
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2026-03-06 08:36 |
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Revised |
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2026-03-26 05:29 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-07 03:22 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-07 08:44 |
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Articles in Press |
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2026-05-07 08:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-29 04:12 |
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Publish the Manuscript Online |
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2026-08-07 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
E74-like E26 transformation-specific transcription factor 3 in gastric cancer: Functions, mechanisms, and clinical translation - unresolved issues
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yun-Jun Yan, Zhen Yang, Ruo-Yu Chao and Jun-Li Shi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yun-Jun Yan, PhD, /, Jinan Vocational College of Nursing, No. 3636 Gangxi Road, Licheng District, Jinan 250102, Shandong Province, China. yanyunjunou@163.com |
| Key Words |
Gastric cancer; E74-like E26 transformation-specific transcription factor 3; Immune evasion; Tumor microenvironment; Prognostic biomarker; Targeted therapy |
| Core Tip |
E74-like E26 transformation-specific transcription factor 3 (ELF3) exhibits context-dependent functions in gastric cancer. Present evidence supports its pro-tumorigenic role through the regulation of epithelial-mesenchymal transition and immune evasion, although functional validation remains required. Patients with high ELF3 expression present with a “cold” tumor phenotype that may limit the responsiveness to immunotherapy. Future research should focus on completing the chain of functional validation and systematically evaluating existing ELF3-targeting compounds in gastric cancer models, particularly in combination with immune checkpoint inhibitors. |
| Publish Date |
2026-08-07 09:40 |
| Citation |
Yan YJ, Yang Z, Chao RY, Shi JL. E74-like E26 transformation-specific transcription factor 3 in gastric cancer: Functions, mechanisms, and clinical translation - unresolved issues. World J Gastrointest Oncol 2026; 18(8): 120240
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i8/120240.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i8.120240 |
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