Publication Name	World Journal of Gastroenterology
Manuscript ID	12025
Country	Mexico

Received	2014-06-18 08:29
Peer-Review Started	2014-06-18 16:22
To Make the First Decision	2014-07-21 14:06
Return for Revision	2014-07-28 16:22
Revised	2014-08-12 05:23
Second Decision	2014-09-30 10:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-30 10:30
Articles in Press	2014-09-30 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-10-21 08:50
Typeset the Manuscript	2015-01-10 19:24
Publish the Manuscript Online	2015-01-20 20:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Case Report
Article Title	Novel LIPA mutations in Mexican siblings with lysosomal acid lipase deficiency
Manuscript Source	Unsolicited Manuscript
All Author List	Yuritzi Santillán-Hernández, Enory Almanza-Miranda, Winnie W Xin, Kendrick Goss, Aurea Vera-Loaiza, María Teresa Gorráez-de la Mora and Raul E Piña-Aguilar
Funding Agency and Grant Number
Corresponding Author	Raul E Piña-Aguilar, MD, Medical Genomics Division, Centro Médico Nacional “20 de Noviembre”, ISSSTE, San Lorenzo #502D, Col. del Valle, Del. Benito Juarez, México City 03100, México. rpina.a@hotmail.comar
Key Words	Cholesteryl ester storage disease; Dyslipidemia; Liver fibrosis; Liver steatosis; Wolman disease
Core Tip	Lysosomal acid lipase-deficiency is a rare genetic disorder related to the metabolism of cholesterol and triglycerides inside the lysosome. In this report, we present the findings from two siblings with no lysosomal acid lipase activity caused by two previously unidentified mutations in exon 4 of LIPA. The patients had early hepatic presentation, including severe cirrhosis and esophageal varices in the elder sibling, underscoring the significant morbidity that can occur at all ages of lysosomal acid lipase-deficiency and highlighting possible compensatory mechanisms in liver function in children.
Publish Date	2015-01-20 20:12
Citation	Santillán-Hernández Y, Almanza-Miranda E, Xin WW, Goss K, Vera-Loaiza A, Gorráez-de la Mora MT, Piña-Aguilar RE. Novel LIPA mutations in Mexican siblings with lysosomal acid lipase deficiency. World J Gastroenterol 2015; 21(3): 1001-1008
URL	http://www.wjgnet.com/1007-9327/full/v21/i3/1001.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i3.1001

Full Article (PDF)	WJG-21-1001.pdf
Full Article (Word)	WJG-21-1001.doc
Manuscript File	12025-Review.docx
Answering Reviewers	12025-Answering reviewers.pdf
Copyright License Agreement	12025-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140618012905.pdf
Non-Native Speakers of English Editing Certificate	12025-Language certificate.pdf
Peer-review Report	12025-Peer review.pdf
Scientific Misconduct Check	12025-CorssCheck.jpg
Scientific Editor Work List	12025-Scientific editor work list.pdf