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Articles Published Processes
8/20/2026 6:54:17 AM | Browse: 3 | Download: 0
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Received |
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2026-02-24 03:13 |
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Peer-Review Started |
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2026-02-24 03:13 |
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First Decision by Editorial Office Director |
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2026-03-09 08:44 |
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Return for Revision |
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2026-03-09 08:44 |
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Revised |
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2026-04-02 06:52 |
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Publication Fee Transferred |
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2026-04-07 06:39 |
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Second Decision by Editor |
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2026-05-18 04:56 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-18 10:08 |
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Articles in Press |
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2026-05-18 10:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-14 00:26 |
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Publish the Manuscript Online |
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2026-08-20 06:54 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Xing Dong, Lu-Li Zheng, Kun Nie and Jian-Xin Wan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Fujian Province |
2021J01355 |
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| Corresponding Author |
Jian-Xin Wan, Chief Physician, Professor, Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China. wanjx@fjmu.edu.cn |
| Key Words |
Human umbilical cord mesenchymal stem cells; Peritoneal fibrosis; Cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway; Epithelial-mesenchymal transition; Inflammation |
| Core Tip |
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is activated in peritoneal fibrosis (PF). This study shows that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate high glucose-induced epithelial-mesenchymal transition and murine PF. Mechanistically, hUC-MSCs exert protective effects by inhibiting the cGAS-STING axis. These findings identify hUC-MSCs as a promising therapeutic strategy to retard PF progression by targeting the cGAS-STING pathway in patients undergoing long-term peritoneal dialysis. |
| Publish Date |
2026-08-20 06:54 |
| Citation |
Dong FX, Zheng LL, Nie K, Wan JX. Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis. World J Stem Cells 2026; 18(8): 120270
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i8/120270.htm |
| DOI |
https://doi.org/10.4252/wjsc.120270 |
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