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Articles Published Processes
6/4/2026 7:37:46 AM | Browse: 0 | Download: 0
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Received |
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2026-02-25 03:19 |
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Peer-Review Started |
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2026-02-25 03:19 |
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First Decision by Editorial Office Director |
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2026-03-13 09:20 |
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Return for Revision |
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2026-03-13 09:20 |
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Revised |
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2026-04-20 00:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-26 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-26 08:19 |
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Articles in Press |
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2026-05-26 08:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-28 01:27 |
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Publish the Manuscript Online |
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2026-06-04 07:37 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammed S Abdulrahman, Omnia Aboelmagd, Ying Zhang, Samy Zaky and Dina Johar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dina Johar, PhD, Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Asma Fahme Street, Cairo 11757, Egypt. dinajohar@gu.edu.eg |
| Key Words |
Hepatitis B virus; Precore/core mutations; Hepatocellular carcinoma; Reactivation; Lamivudine; Entecavir; Tenofovir alafenamide; Tenofovir disoproxil fumarate |
| Core Tip |
Current antiviral treatments can slow down hepatitis B virus (HBV) replication and help improve liver damage. However, they rarely fully clear chronic HBV infections. There is an urgent need for new drugs and better strategies to combat the virus. The hypothesis that seroreactive viral infection is caused by mutation/s in the precore/core is invaluable to elucidating the mechanisms of HBV reactivation. This review re-analyzes clinically significant HBV precore/core mutations affecting pregenomic RNA initiation and synthesis, and their regulation of viral and cellular gene expressions. Further, it analyzes the effects of antivirals lamivudine, entecavir, tenofovir alafenamide, and immune-based strategies on viral reactivation after treatment. |
| Publish Date |
2026-06-04 07:37 |
| Citation |
Abdulrahman MS, Aboelmagd O, Zhang Y, Zaky S, Johar D. Precore/core mutation relatedness to viral reactivation in patients undergoing targeted therapy for hepatitis B virus-related hepatocellular carcinoma. World J Biol Chem 2026; 17(2): 120297
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| URL |
https://www.wjgnet.com/1949-8454/full/v17/i2/120297.htm |
| DOI |
https://doi.org/10.4331/wjbc.v17.i2.120297 |
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