BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/27/2026 8:00:31 AM | Browse: 2 | Download: 0
 |
Received |
|
2026-02-24 05:57 |
|
Peer-Review Started |
|
2026-02-24 06:04 |
|
First Decision by Editorial Office Director |
|
2026-02-28 07:16 |
|
Return for Revision |
|
2026-02-28 07:16 |
|
Revised |
|
2026-03-12 17:29 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-04-21 02:48 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-04-21 09:28 |
|
Articles in Press |
|
2026-04-21 09:28 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-08-19 02:07 |
|
Publish the Manuscript Online |
|
2026-08-27 08:00 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia’s predictive value in sepsis mortality
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jay Pravda |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Jay Pravda, MD, Senior Scientist, Department of Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jay.pravda@protonmail.com |
| Key Words |
Sepsis; Hydrogen peroxide; Proton motive force; Sodium thiosulfate; Dihydrolipoic acid |
| Core Tip |
Despite extensive research spanning several decades and numerous unsuccessful clinical trials, the underlying cause of sepsis remains elusive. However, the characteristic metabolic disturbances observed in sepsis—such as hyperlactatemia, bioenergetic failure, metabolic acidosis, hypothermia, and oxidative stress—can be explained by dissipation of the mitochondrial proton motive force. Emerging evidence suggests that hydrogen peroxide–mediated disruption of this proton gradient represents the proximal mechanism driving the pathogenesis of sepsis. |
| Publish Date |
2026-08-27 08:00 |
| Citation |
Pravda J. Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia’s predictive value in sepsis mortality. World J Crit Care Med 2026; 15(3): 120314
|
| URL |
https://www.wjgnet.com/2220-3141/full/v15/i3/120314.htm |
| DOI |
https://doi.org/10.5492/wjccm.120314 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
