Publication Name	World Journal of Orthopedics
Manuscript ID	12033
Country	Italy

Received	2014-06-18 20:53
Peer-Review Started	2014-06-19 09:16
To Make the First Decision	2014-07-10 17:27
Return for Revision	2014-07-18 09:29
Revised	2014-11-05 00:00
Second Decision	2014-12-10 20:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-17 16:26
Articles in Press	2014-12-17 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-10 11:36
Publish the Manuscript Online	2015-03-19 18:29

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Geriatrics & Gerontology
Manuscript Type	Topic Highlights
Article Title	Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment
Manuscript Source	Invited Manuscript
All Author List	Annamaria Zaia
Funding Agency and Grant Number
Corresponding Author	Annamaria Zaia, PhD, Gerontologic and Geriatric Research Department, Italian National Research Center on Aging, Via Birarelli 8, I-60121 Ancona, Italy. a.zaia@inrca.it
Key Words	Osteoporosis; Fracture risk; Trabecular bone microarchitecture; Fractal analysis; Fractal lacunarity
Core Tip	High-resolution magnetic resonance imaging emerges as a useful tool for in vivo characteriza-tion of trabecular bone architecture (TBA). However, texture analysis is not frequently used as the large number of calculated parameters makes difficult their interpretation. Dealing with complexity and fractal properties of living beings, it is possible to quantify morpho-functional changes in aging and pathology with a limited number of parameters. In this context, fractal lacunarity appears the most suitable approach to TBA texture analysis as it describes discontinuity of bone network and sizes of bone marrow spaces, changes of which are an index of increased fracture risk.
Publish Date	2015-03-19 18:29
Citation	Zaia A. Fractal lacunarity of trabecular bone and magnetic resonance imaging: New perspectives for osteoporotic fracture risk assessment. World J Orthop 2015; 6(2): 221-235
URL	http://www.wjgnet.com/2218-5836/full/v6/i2/221.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i2.221

Full Article (PDF)	WJO-6-221.pdf
Full Article (Word)	WJO-6-221.doc
Manuscript File	12033-Review.doc
Answering Reviewers	12033-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12033-Conflict-of-interest statement.pdf
Copyright License Agreement	12033-Copyright assignment.pdf
Peer-review Report	12033-Peer review(s).pdf
Scientific Misconduct Check	12033-CrossCheck.jpg
Scientific Editor Work List	12033-Scientific editor work list.pdf