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8/25/2026 6:38:35 AM | Browse: 5 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 120338
Country China
Received
2026-02-24 00:56
Peer-Review Started
2026-02-24 00:56
First Decision by Editorial Office Director
2026-03-27 12:51
Return for Revision
2026-03-27 12:51
Revised
2026-04-15 07:34
Publication Fee Transferred
Second Decision by Editor
2026-05-26 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-05-26 08:19
Articles in Press
2026-05-26 08:19
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-14 07:31
Publish the Manuscript Online
2026-08-25 06:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Correspondence
Article Title Letter to the Editor: Helicobacter pylori eradication restores aspirin responsiveness - a thromboinflammatory interpretation
Manuscript Source Invited Manuscript
All Author List Jian-Jiang Song, Ning Li, Yong-Wei Yu and Shuai Liu
ORCID
Author(s) ORCID Number
Yong-Wei Yu http://orcid.org/0000-0001-8319-7707
Shuai Liu http://orcid.org/0009-0009-6551-0224
Funding Agency and Grant Number
Corresponding Author Yong-Wei Yu, Academic Fellow, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words Helicobacter pylori; Aspirin resistance; Thromboinflammation; Platelet reactivity; Antiplatelet pharmacodynamics
Core Tip Helicobacter pylori infection may influence cardiovascular outcomes beyond peptic ulcer disease, particularly in chronic aspirin users. Persistent infection can sustain a thromboinflammatory state that increases platelet turnover and reactivity, thereby weakening effective cyclooxygenase-1 inhibition and producing functional aspirin resistance. We propose that the apparent cardiovascular benefit after eradication may reflect pharmacologic resensitization rather than short-term vascular remodeling. This hypothesis-generating perspective links infection biology with antiplatelet pharmacodynamics and may help explain inter-individual variability in aspirin efficacy.
Publish Date 2026-08-25 06:38
Citation

Song JJ, Li N, Yu YW, Liu S. Letter to the Editor: Helicobacter pylori eradication restores aspirin responsiveness - a thromboinflammatory interpretation. World J Gastroenterol 2026; 32(36): 120338

URL https://www.wjgnet.com/1007-9327/full/v32/i36/120338.htm
DOI https://doi.org/10.3748/wjg.120338
Full Article (PDF) WJG-32-120338-with-cover.pdf
Manuscript File 120338_Auto_Edited_024611.docx
Answering Reviewers 120338-answering-reviewers.pdf
Audio Core Tip 120338-audio.mp3
Conflict-of-Interest Disclosure Form 120338-conflict-of-interest-statement.pdf
Copyright License Agreement 120338-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 120338-non-native-speakers.pdf
Peer-review Report 120338-peer-reviews.pdf
Scientific Misconduct Check 120338-scientific-misconduct-check.png
CrossCheck Report 120338-crosscheck-report.pdf