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Articles Published Processes
2/11/2015 4:38:00 PM | Browse: 1087 | Download: 1316
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Received |
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2014-06-19 09:19 |
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Peer-Review Started |
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2014-06-19 19:12 |
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To Make the First Decision |
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2014-07-21 14:04 |
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Return for Revision |
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2014-07-28 16:27 |
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Revised |
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2014-09-03 14:58 |
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Second Decision |
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2014-11-17 12:03 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 09:08 |
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Articles in Press |
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2014-11-19 09:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-02 21:56 |
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Typeset the Manuscript |
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2015-01-31 16:29 |
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Publish the Manuscript Online |
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2015-02-11 16:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qin He, Jin-Ke Li, Fang Li, Ru-Gui Li, Guo-Qing Zhan, Gang Li, Wei-Xing Du and Hua-Bing Tan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Bureau of Public Health of Hubei Province |
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| Corresponding Author |
Hua-Bing Tan, Professor, Department of Infectious Diseases and Lab of Liver Disease, Renmin Hospital, Hubei University of Medicine, 39 Chaoyangzhong Road, Shiyan 442000, Hubei Province, China. tanhb_2013@163.com
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| Key Words |
Gypenosides; Type 2 diabetes mellitus; Non-alcoholic fatty liver; PPARγ; Cytochrome P4501A1 |
| Core Tip |
Gypenosides (GPs) are one of the most phar-macologically active components in G. pentaphyllum. Intervention with GPs significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, blood glucose, insulin, triglycerides and total cholesterol in type 2 diabetes mellitus and non-alcoholic fatty liver disease (T2DM-NAFLD) model rats, down-regulated the expression of TNF-α, NF-κB, rabbit anti-proliferator activated receptory (PPARγ) and rabbit anti-cytochrome P4501A1 (CYP1A1) mRNA, decreased the infiltration of liver fats and reversed the histopathological changes in a dose-dependent manner. These findings suggest that GPs have a protective effect against T2DM-NAFLD by down-regulating the expression of TNF-α and NF-κB proteins, and PPARγ and CYP4501A1 mRNAs.
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| Publish Date |
2015-02-11 16:38 |
| Citation |
He Q, Li JK, Li F, Li RG, Zhan GQ, Li G, Du WX, Tan HB. Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats. World J Gastroenterol 2015; 21(7): 2058-2066 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i7/2058.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i7.2058 |
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