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8/26/2026 5:34:15 AM | Browse: 1 | Download: 0
Publication Name World Journal of Cardiology
Manuscript ID 120391
Country United States
Received
2026-02-25 02:57
Peer-Review Started
2026-02-25 02:58
First Decision by Editorial Office Director
2026-03-09 08:54
Return for Revision
2026-03-09 08:54
Revised
2026-03-22 22:34
Publication Fee Transferred
Second Decision by Editor
2026-04-14 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-04-14 07:44
Articles in Press
2026-04-14 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-07-06 02:48
Publish the Manuscript Online
2026-08-26 05:34
ISSN 1949-8462 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Editorial
Article Title Landiolol, electrical remodeling, and the emerging biology of ventricular arrhythmia control
Manuscript Source Invited Manuscript
All Author List Maryam Salimi, Ramesh Hariharan and Khashayar Hematpour
ORCID
Author(s) ORCID Number
Maryam Salimi http://orcid.org/0000-0001-9771-7048
Khashayar Hematpour http://orcid.org/0000-0001-5714-8338
Funding Agency and Grant Number
Corresponding Author Khashayar Hematpour, Department of Advanced Cardiopulmonary Therapies and Transplantations (ACTAT), University of Texas Health Sciences Center, McGovern Medical School, 6400 Fannin St, Houston, TX 77030, United States. khashayar.hematpour@gmail.com
Key Words Sepsis; Landiolol; Ventricular arrhythmia; Electrical remodeling; Connexin-43; NaV1.5; β1-selective blockade; Conduction heterogeneity
Core Tip Ventricular arrhythmias in sepsis may not be only a consequence of elevated heart rate, but rather the result of inflammation-driven electrical instability within the myocardium. Experimental data suggest that landiolol may influence this process by affecting key conduction proteins, including connexin-43 and NaV1.5. This perspective shifts the focus from simple rate control toward potential modulation of the arrhythmogenic substrate, highlighting the need for more targeted clinical investigation.
Publish Date 2026-08-26 05:34
Citation

Salimi M, Hariharan R, Hematpour K. Landiolol, electrical remodeling, and the emerging biology of ventricular arrhythmia control. World J Cardiol 2026; 18(8): 120391

URL https://www.wjgnet.com/1949-8462/full/v18/i8/120391.htm
DOI https://doi.org/10.4330/wjc.120391
Full Article (PDF) WJC-18-120391-with-cover.pdf
Manuscript File 120391_Auto_Edited_005817.docx
Answering Reviewers 120391-answering-reviewers.pdf
Audio Core Tip 120391-audio.m4a
Conflict-of-Interest Disclosure Form 120391-conflict-of-interest-statement.pdf
Copyright License Agreement 120391-copyright-assignment.pdf
Peer-review Report 120391-peer-reviews.pdf
Scientific Misconduct Check 120391-scientific-misconduct-check.png
CrossCheck Report 120391-crosscheck-report.pdf