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Articles Published Processes
9/24/2026 12:48:57 AM | Browse: 3 | Download: 0
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Received |
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2026-02-27 03:26 |
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Peer-Review Started |
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2026-02-27 03:26 |
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First Decision by Editorial Office Director |
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2026-03-09 08:54 |
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Return for Revision |
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2026-03-09 08:54 |
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Revised |
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2026-03-22 20:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-21 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-21 07:18 |
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Articles in Press |
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2026-04-21 07:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-16 00:20 |
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Publish the Manuscript Online |
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2026-09-24 00:48 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Editorial |
| Article Title |
Landiolol and septic ventricular arrhythmias: Revisiting the inflammation–fibrosis–Nav1.5/Cx43 electro-structural axis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jiao Tang, Xue Deng, Ting Luo, Zhuoma Gesang, Zi-Ran Jia, Quzhun Danzeng and Tao Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xizang Autonomous Region Science and Technology Program |
XZ202501YD0006 |
| Medical Science Research Project of Sichuan Province |
S23014 |
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| Corresponding Author |
Tao Wang, Chief Physician, MD, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 South Renmin Road, Chengdu 610041, Sichuan Province, China. 44871875@qq.com |
| Key Words |
Sepsis; Ventricular arrhythmia; Landiolol; β1 blocker; Cx43; Nav1.5; Conduction dispersion; Fibrosis; Electro structural remodeling; Precision critical care |
| Core Tip |
Hu et al demonstrated that landiolol reduced ventricular arrhythmia burden in a septic rat model while attenuating inflammation, apoptosis, and fibrosis, improving conduction heterogeneity, and being accompanied by reciprocal changes in Cx43 and Nav1.5 expression. The key message is conceptual rather than definitive: Ultra-short-acting beta1 blockade may benefit selected septic patients by modulating an inflammation-fibrosis-Nav1.5/Cx43 electro-structural axis, not merely by slowing heart rate. Future studies should explicitly link expression to function through INa and gap-junction or hemichannel assays, define the safe dose and time window, and translate this framework through phenotype-guided clinical implementation. |
| Publish Date |
2026-09-24 00:48 |
| Citation |
Tang J, Deng X, Luo T, Gesang Z, Jia ZR, Danzeng Q, Wang T. Landiolol and septic ventricular arrhythmias: Revisiting the inflammation–fibrosis–Nav1.5/Cx43 electro-structural axis. World J Cardiol 2026; 18(9): 120433
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i9/120433.htm |
| DOI |
https://doi.org/10.4330/wjc.120433 |
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