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Articles Published Processes
8/5/2026 5:45:43 AM | Browse: 1 | Download: 0
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Received |
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2026-02-28 01:24 |
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Peer-Review Started |
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2026-02-28 01:24 |
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First Decision by Editorial Office Director |
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2026-03-20 11:30 |
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Return for Revision |
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2026-03-20 11:30 |
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Revised |
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2026-04-23 16:45 |
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Publication Fee Transferred |
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2026-04-28 09:32 |
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Second Decision by Editor |
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2026-06-22 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-22 06:41 |
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Articles in Press |
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2026-06-22 06:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-13 09:31 |
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Publish the Manuscript Online |
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2026-08-05 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Yun Zhuo, Xiao-Ya Guo, Xiao-Ming Liu, Ming-Mei Shang, Shan Xue, Lei Peng and Zhi-Guo Guo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82400621 |
| Anhui Provincial Health Science and Technology Project |
AHWJ2024Aa20059 |
| Anhui Province Traditional Chinese Medicine Inheritance Innovation Project |
2024CCCX271 |
| Anhui Province Education Department Project |
2023jyxm1156 |
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| Corresponding Author |
Zhi-Guo Guo, MD, Professor, Department of Gastroenterology, Suzhou Hospital of Anhui Medical University, No. 616 Bianyangsan Road, Suzhou 234000, Anhui Province, China. guozhiguo@ahmu.edu.cn |
| Key Words |
Ulcerative colitis; Extracts of Gleditsia sinensis Lam. thorn; Peroxisome proliferator-activated receptor gamma/glutathione peroxidase 4; Bile acids; Ferroptosis |
| Core Tip |
Extracts of Gleditsia sinensis Lam. thorn (EGST) ameliorates dextran sulfate sodium-induced ulcerative colitis. EGST inhibited the ferroptosis of erastin-induced Caco-2 cells. EGST regulates nitric oxide and reactive oxygen species inhibit lipid peroxidation. EGST activated the peroxisome proliferator-activated receptor gamma/glutathione peroxidase 4 signaling pathway and inhibit ferroptosis. We report for the first time that EGST alleviates colitis in mice by regulating taurohyodeoxycholic acid. |
| Publish Date |
2026-08-05 05:45 |
| Citation |
Zhuo ZY, Guo XY, Liu XM, Shang MM, Xue S, Peng L, Guo ZG. Extracts of Gleditsia sinensis Lam. thorn ameliorates ulcerative colitis through PPARγ/GPX4 pathway-mediated inhibition of enterocyte ferroptosis. World J Gastroenterol 2026; 32(32): 120450
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i32/120450.htm |
| DOI |
https://doi.org/10.3748/wjg.120450 |
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